Lymphadenopathy – GO – LCGAR: Long COVID Gene Association Resource

Lymphadenopathy (HP:0002716)

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	cellular response to interleukin-2 (GO:0071352)	1.482e-8	0.000001912	1070.46	19297.66
2	interleukin-2-mediated signaling pathway (GO:0038110)	1.482e-8	0.000001912	1070.46	19297.66
3	positive regulation of killing of cells of other organism (GO:0051712)	0.000003371	0.0001112	1249.13	15739.23
4	T cell apoptotic process (GO:0070231)	0.000004719	0.0001353	999.25	12254.80
5	positive regulation of cell killing (GO:0031343)	0.00002354	0.0005607	384.17	4094.01
6	B cell receptor signaling pathway (GO:0050853)	5.342e-7	0.00003446	275.93	3985.12
7	regulation of T cell differentiation (GO:0045580)	8.148e-7	0.00004204	237.55	3330.49
8	positive thymic T cell selection (GO:0045059)	0.002498	0.01953	555.17	3326.77
9	regulation of neutrophil activation (GO:1902563)	0.002498	0.01953	555.17	3326.77
10	regulation of neutrophil degranulation (GO:0043313)	0.002498	0.01953	555.17	3326.77
11	positive regulation of mast cell activation involved in immune response (GO:0033008)	0.002498	0.01953	555.17	3326.77
12	negative regulation of regulatory T cell differentiation (GO:0045590)	0.002498	0.01953	555.17	3326.77
13	positive regulation of lymphocyte differentiation (GO:0045621)	0.00004255	0.0009147	277.39	2791.90
14	regulation of superoxide metabolic process (GO:0090322)	0.002997	0.02035	444.11	2580.41
15	lymphocyte apoptotic process (GO:0070227)	0.002997	0.02035	444.11	2580.41
16	taurine metabolic process (GO:0019530)	0.002997	0.02035	444.11	2580.41
17	regulation of T cell tolerance induction (GO:0002664)	0.003495	0.02199	370.07	2093.27
18	release of sequestered calcium ion into cytosol by endoplasmic reticulum (GO:1903514)	0.003495	0.02199	370.07	2093.27
19	regulation of regulatory T cell differentiation (GO:0045589)	0.00007266	0.001339	207.98	1981.99
20	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269)	0.003994	0.02247	317.19	1751.86
21	regulation of alpha-beta T cell proliferation (GO:0046640)	0.003994	0.02247	317.19	1751.86
22	immunological synapse formation (GO:0001771)	0.003994	0.02247	317.19	1751.86
23	positive regulation of monocyte chemotactic protein-1 production (GO:0071639)	0.003994	0.02247	317.19	1751.86
24	cellular response to interleukin-9 (GO:0071355)	0.004492	0.02247	277.53	1500.17
25	positive regulation of B cell differentiation (GO:0045579)	0.004492	0.02247	277.53	1500.17
26	regulation of leukocyte degranulation (GO:0043300)	0.004492	0.02247	277.53	1500.17
27	positive regulation of mast cell degranulation (GO:0043306)	0.004492	0.02247	277.53	1500.17
28	interleukin-9-mediated signaling pathway (GO:0038113)	0.004492	0.02247	277.53	1500.17
29	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	0.0001252	0.002153	155.92	1401.11
30	defense response to tumor cell (GO:0002357)	0.004990	0.02247	246.68	1307.49
31	regulation of cell activation (GO:0050865)	0.004990	0.02247	246.68	1307.49
32	immunoglobulin mediated immune response (GO:0016064)	0.004990	0.02247	246.68	1307.49
33	cellular response to increased oxygen levels (GO:0036295)	0.005488	0.02247	222.00	1155.57
34	positive regulation of bone resorption (GO:0045780)	0.005488	0.02247	222.00	1155.57
35	regulation of stress-activated protein kinase signaling cascade (GO:0070302)	0.005488	0.02247	222.00	1155.57
36	T cell homeostasis (GO:0043029)	0.005488	0.02247	222.00	1155.57
37	B cell mediated immunity (GO:0019724)	0.005488	0.02247	222.00	1155.57
38	regulation of monocyte chemotactic protein-1 production (GO:0071637)	0.005488	0.02247	222.00	1155.57
39	regulation of myeloid leukocyte mediated immunity (GO:0002886)	0.005488	0.02247	222.00	1155.57
40	V(D)J recombination (GO:0033151)	0.005488	0.02247	222.00	1155.57
41	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267)	0.005488	0.02247	222.00	1155.57
42	positive regulation of programmed cell death (GO:0043068)	1.372e-7	0.00001180	70.14	1108.31
43	T cell differentiation (GO:0030217)	0.0001826	0.002747	127.89	1100.92
44	regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	0.0001917	0.002747	124.69	1067.29
45	negative regulation of B cell proliferation (GO:0030889)	0.005985	0.02401	201.81	1032.95
46	antigen receptor-mediated signaling pathway (GO:0050851)	0.000001425	0.00006127	72.96	982.16
47	cellular response to interleukin-15 (GO:0071350)	0.006482	0.02401	184.98	932.06
48	regulation of homotypic cell-cell adhesion (GO:0034110)	0.006482	0.02401	184.98	932.06
49	macrophage activation involved in immune response (GO:0002281)	0.006482	0.02401	184.98	932.06
50	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	0.006482	0.02401	184.98	932.06
51	interleukin-15-mediated signaling pathway (GO:0035723)	0.006482	0.02401	184.98	932.06
52	cellular response to low-density lipoprotein particle stimulus (GO:0071404)	0.006979	0.02401	170.74	847.70
53	negative regulation of T cell differentiation (GO:0045581)	0.006979	0.02401	170.74	847.70
54	T cell differentiation in thymus (GO:0033077)	0.006979	0.02401	170.74	847.70
55	positive regulation of superoxide anion generation (GO:0032930)	0.006979	0.02401	170.74	847.70
56	growth hormone receptor signaling pathway via JAK-STAT (GO:0060397)	0.006979	0.02401	170.74	847.70
57	positive regulation of leukocyte degranulation (GO:0043302)	0.006979	0.02401	170.74	847.70
58	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	0.00002391	0.0005607	73.43	781.36
59	regulation of superoxide anion generation (GO:0032928)	0.007476	0.02478	158.54	776.21
60	regulation of lymphocyte activation (GO:0051249)	0.007476	0.02478	158.54	776.21
61	peptidyl-tyrosine modification (GO:0018212)	0.0003416	0.004638	92.30	736.71
62	apoptotic process (GO:0006915)	0.000003448	0.0001112	58.04	730.03
63	positive regulation of alpha-beta T cell proliferation (GO:0046641)	0.007973	0.02478	147.96	714.91
64	neutrophil activation (GO:0042119)	0.007973	0.02478	147.96	714.91
65	positive regulation of endothelial cell apoptotic process (GO:2000353)	0.007973	0.02478	147.96	714.91
66	regulation of mast cell degranulation (GO:0043304)	0.007973	0.02478	147.96	714.91
67	B cell activation involved in immune response (GO:0002312)	0.007973	0.02478	147.96	714.91
68	necroptotic process (GO:0070266)	0.007973	0.02478	147.96	714.91
69	regulation of extrinsic apoptotic signaling pathway (GO:2001236)	0.0004462	0.005482	80.35	619.92
70	positive regulation of cell adhesion mediated by integrin (GO:0033630)	0.008966	0.02570	130.54	615.43
71	T cell migration (GO:0072678)	0.008966	0.02570	130.54	615.43
72	regulation of B cell differentiation (GO:0045577)	0.008966	0.02570	130.54	615.43
73	regulation of multicellular organism growth (GO:0040014)	0.008966	0.02570	130.54	615.43
74	positive regulation of interleukin-4 production (GO:0032753)	0.008966	0.02570	130.54	615.43
75	programmed necrotic cell death (GO:0097300)	0.008966	0.02570	130.54	615.43
76	regulation of platelet aggregation (GO:0090330)	0.008966	0.02570	130.54	615.43
77	cellular response to interleukin-7 (GO:0098761)	0.009462	0.02597	123.28	574.57
78	myeloid cell activation involved in immune response (GO:0002275)	0.009462	0.02597	123.28	574.57
79	interleukin-7-mediated signaling pathway (GO:0038111)	0.009462	0.02597	123.28	574.57
80	peptidyl-tyrosine phosphorylation (GO:0018108)	0.0005185	0.006081	74.34	562.35
81	positive regulation of alpha-beta T cell activation (GO:0046635)	0.009957	0.02676	116.79	538.34
82	growth hormone receptor signaling pathway (GO:0060396)	0.009957	0.02676	116.79	538.34
83	extrinsic apoptotic signaling pathway (GO:0097191)	0.0005645	0.006332	71.14	532.12
84	extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)	0.01045	0.02724	110.94	506.01
85	neuron apoptotic process (GO:0051402)	0.01045	0.02724	110.94	506.01
86	histone ubiquitination (GO:0016574)	0.01045	0.02724	110.94	506.01
87	negative regulation of B cell activation (GO:0050869)	0.01095	0.02797	105.66	476.99
88	regulation of platelet activation (GO:0010543)	0.01095	0.02797	105.66	476.99
89	negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	0.0006964	0.007367	63.82	463.95
90	activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	0.0007138	0.007367	63.01	456.50
91	regulation of interleukin-4 production (GO:0032673)	0.01144	0.02839	100.85	450.83
92	regulation of B cell receptor signaling pathway (GO:0050855)	0.01144	0.02839	100.85	450.83
93	positive regulation of epithelial cell apoptotic process (GO:1904037)	0.01144	0.02839	100.85	450.83
94	lymphocyte differentiation (GO:0030098)	0.0007674	0.007508	60.70	435.34
95	B cell activation (GO:0042113)	0.0007857	0.007508	59.96	428.66
96	histone monoubiquitination (GO:0010390)	0.01194	0.02906	96.46	427.12
97	immune response-activating cell surface receptor signaling pathway (GO:0002429)	0.01194	0.02906	96.46	427.12
98	receptor signaling pathway via STAT (GO:0097696)	0.01243	0.02998	92.44	405.55
99	positive regulation of calcium ion transmembrane transport (GO:1904427)	0.01342	0.03148	85.32	367.79
100	positive regulation of erythrocyte differentiation (GO:0045648)	0.01342	0.03148	85.32	367.79
101	release of sequestered calcium ion into cytosol (GO:0051209)	0.01342	0.03148	85.32	367.79
102	leukocyte cell-cell adhesion (GO:0007159)	0.01392	0.03149	82.15	351.18
103	positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)	0.01392	0.03149	82.15	351.18
104	regulation of B cell activation (GO:0050864)	0.01392	0.03149	82.15	351.18
105	cellular response to epidermal growth factor stimulus (GO:0071364)	0.01392	0.03149	82.15	351.18
106	extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	0.01490	0.03314	76.48	321.69
107	positive regulation of lipid kinase activity (GO:0090218)	0.01490	0.03314	76.48	321.69
108	receptor signaling pathway via JAK-STAT (GO:0007259)	0.01540	0.03366	73.93	308.54
109	regulation of developmental growth (GO:0048638)	0.01540	0.03366	73.93	308.54
110	B cell proliferation (GO:0042100)	0.01589	0.03416	71.54	296.32
111	positive regulation of interleukin-10 production (GO:0032733)	0.01589	0.03416	71.54	296.32
112	positive regulation of calcium ion transport into cytosol (GO:0010524)	0.01687	0.03455	67.20	274.29
113	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	0.01687	0.03455	67.20	274.29
114	regulation of cell adhesion mediated by integrin (GO:0033628)	0.01687	0.03455	67.20	274.29
115	positive regulation of interleukin-12 production (GO:0032735)	0.01687	0.03455	67.20	274.29
116	regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	0.01737	0.03528	65.22	264.33
117	cellular response to cytokine stimulus (GO:0071345)	0.00006234	0.001237	27.21	263.51
118	macrophage activation (GO:0042116)	0.01786	0.03600	63.35	255.00
119	positive regulation of myeloid cell differentiation (GO:0045639)	0.01835	0.03642	61.59	246.23
120	regulation of erythrocyte differentiation (GO:0045646)	0.01835	0.03642	61.59	246.23
121	regulation of apoptotic signaling pathway (GO:2001233)	0.01884	0.03668	59.92	237.98
122	response to estradiol (GO:0032355)	0.01884	0.03668	59.92	237.98
123	protein monoubiquitination (GO:0006513)	0.01933	0.03668	58.34	230.20
124	negative regulation of lymphocyte proliferation (GO:0050672)	0.01933	0.03668	58.34	230.20
125	response to peptide (GO:1901652)	0.01933	0.03668	58.34	230.20
126	DNA recombination (GO:0006310)	0.01933	0.03668	58.34	230.20
127	lymphocyte migration (GO:0072676)	0.01983	0.03734	56.84	222.86
128	enzyme linked receptor protein signaling pathway (GO:0007167)	0.002110	0.01944	35.96	221.57
129	response to growth factor (GO:0070848)	0.02032	0.03798	55.42	215.92
130	positive regulation of apoptotic process (GO:0043065)	0.0004082	0.005266	27.48	214.43
131	positive regulation of T cell differentiation (GO:0045582)	0.02130	0.03953	52.77	203.13
132	regulation of endothelial cell apoptotic process (GO:2000351)	0.02179	0.04015	51.54	197.22
133	T cell receptor signaling pathway (GO:0050852)	0.002677	0.02031	31.79	188.27
134	regulation of B cell proliferation (GO:0030888)	0.02277	0.04166	49.25	186.27
135	cytokine-mediated signaling pathway (GO:0019221)	0.0001665	0.002685	20.93	182.12
136	regulation of interleukin-10 production (GO:0032653)	0.02375	0.04225	47.15	176.34
137	regulation of MAPK cascade (GO:0043408)	0.002950	0.02035	30.22	176.08
138	cellular response to mechanical stimulus (GO:0071260)	0.02424	0.04225	46.16	171.72
139	regulation of stress-activated MAPK cascade (GO:0032872)	0.02424	0.04225	46.16	171.72
140	receptor internalization (GO:0031623)	0.02424	0.04225	46.16	171.72
141	positive regulation of reactive oxygen species metabolic process (GO:2000379)	0.02424	0.04225	46.16	171.72
142	cellular defense response (GO:0006968)	0.02424	0.04225	46.16	171.72
143	regulation of complement activation (GO:0030449)	0.02473	0.04281	45.22	167.30
144	regulation of interleukin-12 production (GO:0032655)	0.02521	0.04337	44.31	163.08
145	regulation of release of sequestered calcium ion into cytosol (GO:0051279)	0.02570	0.04360	43.44	159.04
146	response to peptide hormone (GO:0043434)	0.02570	0.04360	43.44	159.04
147	regulation of immune response (GO:0050776)	0.003419	0.02199	27.98	158.91
148	positive regulation of B cell activation (GO:0050871)	0.02619	0.04360	42.60	155.17
149	regulation of immune effector process (GO:0002697)	0.02619	0.04360	42.60	155.17
150	positive regulation of chemokine production (GO:0032722)	0.02619	0.04360	42.60	155.17
151	regulation of humoral immune response (GO:0002920)	0.02668	0.04412	41.80	151.46
152	blood vessel morphogenesis (GO:0048514)	0.02766	0.04545	40.27	144.50
153	receptor metabolic process (GO:0043112)	0.02863	0.04617	38.86	138.07
154	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	0.02863	0.04617	38.86	138.07
155	regulation of phagocytosis (GO:0050764)	0.02863	0.04617	38.86	138.07
156	positive regulation of apoptotic signaling pathway (GO:2001235)	0.02912	0.04637	38.18	135.03
157	response to organic cyclic compound (GO:0014070)	0.02960	0.04686	37.53	132.12
158	B cell differentiation (GO:0030183)	0.03009	0.04705	36.91	129.31
159	positive regulation of interleukin-8 production (GO:0032757)	0.03009	0.04705	36.91	129.31
160	positive regulation of cysteine-type endopeptidase activity (GO:2001056)	0.03058	0.04752	36.30	126.60
161	protein autoubiquitination (GO:0051865)	0.03204	0.04949	34.59	119.03
162	positive regulation of T cell proliferation (GO:0042102)	0.03252	0.04994	34.06	116.68
163	neutrophil chemotaxis (GO:0030593)	0.03446	0.05261	32.08	108.04
164	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	0.03495	0.05278	31.62	106.05
165	Fc-gamma receptor signaling pathway (GO:0038094)	0.03543	0.05278	31.17	104.12
166	granulocyte chemotaxis (GO:0071621)	0.03591	0.05278	30.74	102.25
167	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	0.03640	0.05278	30.32	100.44
168	regulation of cytokine-mediated signaling pathway (GO:0001959)	0.03640	0.05278	30.32	100.44
169	cellular response to amino acid starvation (GO:0034198)	0.03640	0.05278	30.32	100.44
170	positive regulation of T cell activation (GO:0050870)	0.03688	0.05278	29.90	98.68
171	response to amino acid starvation (GO:1990928)	0.03688	0.05278	29.90	98.68
172	integrin-mediated signaling pathway (GO:0007229)	0.03688	0.05278	29.90	98.68
173	cellular response to hormone stimulus (GO:0032870)	0.03736	0.05278	29.50	96.98
174	establishment of protein localization to organelle (GO:0072594)	0.03736	0.05278	29.50	96.98
175	positive regulation of interleukin-6 production (GO:0032755)	0.03736	0.05278	29.50	96.98
176	protein import into nucleus (GO:0006606)	0.03736	0.05278	29.50	96.98
177	neutrophil migration (GO:1990266)	0.03785	0.05278	29.11	95.32
178	positive regulation of tumor necrosis factor production (GO:0032760)	0.03785	0.05278	29.11	95.32
179	import into nucleus (GO:0051170)	0.03785	0.05278	29.11	95.32
180	negative regulation of blood vessel morphogenesis (GO:2000181)	0.03833	0.05317	28.73	93.72
181	positive regulation of cell adhesion (GO:0045785)	0.03930	0.05422	28.00	90.64
182	regulation of interleukin-8 production (GO:0032677)	0.03978	0.05430	27.65	89.16
183	positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	0.03978	0.05430	27.65	89.16
184	negative regulation of angiogenesis (GO:0016525)	0.04267	0.05794	25.72	81.12
185	regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	0.04363	0.05863	25.13	78.70
186	protein import (GO:0017038)	0.04363	0.05863	25.13	78.70
187	protein complex oligomerization (GO:0051259)	0.04411	0.05896	24.85	77.54
188	innate immune response (GO:0045087)	0.009440	0.02597	16.41	76.51
189	positive regulation of cellular component biogenesis (GO:0044089)	0.04507	0.05963	24.30	75.31
190	T cell activation (GO:0042110)	0.04507	0.05963	24.30	75.31
191	regulation of vesicle-mediated transport (GO:0060627)	0.04699	0.06185	23.27	71.15
192	positive regulation of cold-induced thermogenesis (GO:0120162)	0.04747	0.06216	23.03	70.18
193	cellular response to chemical stress (GO:0062197)	0.04938	0.06434	22.10	66.48
194	protein localization to nucleus (GO:0034504)	0.05176	0.06711	21.04	62.31
195	regulation of interleukin-6 production (GO:0032675)	0.05367	0.06923	20.27	59.28
196	regulation of apoptotic process (GO:0042981)	0.005019	0.02247	11.16	59.11
197	Fc-epsilon receptor signaling pathway (GO:0038095)	0.05415	0.06942	20.08	58.56
198	protein-containing complex subunit organization (GO:0043933)	0.05462	0.06942	19.90	57.85
199	Fc receptor signaling pathway (GO:0038093)	0.05462	0.06942	19.90	57.85
200	positive regulation of metabolic process (GO:0009893)	0.05510	0.06952	19.72	57.16
201	positive regulation of cellular component organization (GO:0051130)	0.05557	0.06952	19.54	56.49
202	response to lipid (GO:0033993)	0.05557	0.06952	19.54	56.49
203	cellular response to lectin (GO:1990858)	0.05605	0.06952	19.37	55.82
204	stimulatory C-type lectin receptor signaling pathway (GO:0002223)	0.05605	0.06952	19.37	55.82
205	regulation of protein-containing complex assembly (GO:0043254)	0.05652	0.06977	19.20	55.17
206	positive regulation of protein-containing complex assembly (GO:0031334)	0.05747	0.07061	18.87	53.91
207	innate immune response activating cell surface receptor signaling pathway (GO:0002220)	0.05794	0.07085	18.71	53.30
208	protein homooligomerization (GO:0051260)	0.05889	0.07167	18.40	52.10
209	cellular response to organic substance (GO:0071310)	0.05984	0.07237	18.09	50.96
210	phosphorylation (GO:0016310)	0.01615	0.03443	12.31	50.78
211	regulation of tumor necrosis factor production (GO:0032680)	0.06031	0.07237	17.95	50.40
212	defense response to symbiont (GO:0140546)	0.06031	0.07237	17.95	50.40
213	transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	0.01645	0.03455	12.18	50.03
214	defense response to virus (GO:0051607)	0.06456	0.07711	16.72	45.80
215	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	0.06597	0.07844	16.34	44.43
216	regulation of inflammatory response to antigenic stimulus (GO:0002861)	0.06644	0.07863	16.22	43.98
217	receptor-mediated endocytosis (GO:0006898)	0.06926	0.08159	15.53	41.47
218	protein phosphorylation (GO:0006468)	0.02421	0.04225	9.87	36.71
219	cellular response to growth factor stimulus (GO:0071363)	0.07627	0.08903	14.04	36.12
220	cellular response to starvation (GO:0009267)	0.07627	0.08903	14.04	36.12
221	positive regulation of protein kinase B signaling (GO:0051897)	0.07766	0.09026	13.77	35.19
222	positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	0.08230	0.09522	12.95	32.35
223	positive regulation of intracellular signal transduction (GO:1902533)	0.02895	0.04637	8.94	31.65
224	defense response to bacterium (GO:0042742)	0.08461	0.09746	12.58	31.07
225	negative regulation of immune response (GO:0050777)	0.08554	0.09808	12.44	30.58
226	regulation of programmed cell death (GO:0043067)	0.09289	0.1056	11.40	27.08
227	regulation of angiogenesis (GO:0045765)	0.09701	0.1098	10.88	25.39
228	regulation of protein kinase B signaling (GO:0051896)	0.09883	0.1113	10.67	24.70
229	negative regulation of inflammatory response (GO:0050728)	0.1011	0.1134	10.42	23.87
230	positive regulation of protein modification process (GO:0031401)	0.1020	0.1139	10.32	23.55
231	regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	0.1065	0.1185	9.85	22.05
232	inflammatory response (GO:0006954)	0.1093	0.1210	9.59	21.23
233	regulation of ERK1 and ERK2 cascade (GO:0070372)	0.1128	0.1244	9.26	20.20
234	positive regulation of signal transduction (GO:0009967)	0.1191	0.1307	8.74	18.59
235	positive regulation of phosphorylation (GO:0042327)	0.1196	0.1307	8.70	18.48
236	cellular component assembly (GO:0022607)	0.1231	0.1340	8.43	17.66
237	regulation of protein phosphorylation (GO:0001932)	0.1253	0.1358	8.27	17.18
238	protein-containing complex assembly (GO:0065003)	0.1258	0.1358	8.24	17.08
239	DNA metabolic process (GO:0006259)	0.1302	0.1400	7.94	16.18
240	MAPK cascade (GO:0000165)	0.1416	0.1516	7.24	14.16
241	positive regulation of cytokine production (GO:0001819)	0.1555	0.1655	6.54	12.17
242	intracellular protein transport (GO:0006886)	0.1559	0.1655	6.52	12.12
243	positive regulation of multicellular organismal process (GO:0051240)	0.1597	0.1689	6.35	11.64
244	cellular response to DNA damage stimulus (GO:0006974)	0.1619	0.1705	6.25	11.39
245	cellular protein modification process (GO:0006464)	0.08986	0.1026	4.64	11.17
246	positive regulation of protein phosphorylation (GO:0001934)	0.1708	0.1791	5.89	10.41
247	negative regulation of programmed cell death (GO:0043069)	0.1750	0.1828	5.73	9.99
248	negative regulation of apoptotic process (GO:0043066)	0.2177	0.2256	4.48	6.83
249	neutrophil activation involved in immune response (GO:0002283)	0.2177	0.2256	4.48	6.83
250	protein ubiquitination (GO:0016567)	0.2336	0.2411	4.13	6.00
251	negative regulation of transcription by RNA polymerase II (GO:0000122)	0.2939	0.3021	3.14	3.85
252	regulation of cell population proliferation (GO:0042127)	0.3227	0.3290	2.80	3.17
253	regulation of transcription by RNA polymerase II (GO:0006357)	0.3040	0.3112	2.02	2.40
254	positive regulation of transcription by RNA polymerase II (GO:0045944)	0.3717	0.3776	2.34	2.31
255	negative regulation of transcription, DNA-templated (GO:0045892)	0.3847	0.3893	2.23	2.13
256	regulation of gene expression (GO:0010468)	0.4258	0.4291	1.95	1.66
257	positive regulation of transcription, DNA-templated (GO:0045893)	0.4566	0.4583	1.77	1.39
258	regulation of transcription, DNA-templated (GO:0006355)	0.6959	0.6959	0.88	0.32

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	glucocorticoid receptor binding (GO:0035259)	0.004492	0.02545	277.53	1500.17
2	tumor necrosis factor-activated receptor activity (GO:0005031)	0.004492	0.02545	277.53	1500.17
3	non-membrane spanning protein tyrosine kinase activity (GO:0004715)	0.0001327	0.002172	151.19	1349.73
4	phosphotyrosine residue binding (GO:0001784)	0.0001485	0.002172	142.54	1256.48
5	protein phosphorylated amino acid binding (GO:0045309)	0.0001917	0.002172	124.69	1067.29
6	death receptor activity (GO:0005035)	0.005985	0.02907	201.81	1032.95
7	phospholipase binding (GO:0043274)	0.006979	0.02966	170.74	847.70
8	endodeoxyribonuclease activity (GO:0004520)	0.009957	0.03762	116.79	538.34
9	wide pore channel activity (GO:0022829)	0.01243	0.04227	92.44	405.55
10	protein tyrosine kinase activity (GO:0004713)	0.001264	0.01074	46.90	312.97
11	channel activity (GO:0015267)	0.02277	0.06841	49.25	186.27
12	endonuclease activity (GO:0004519)	0.02521	0.06841	44.31	163.08
13	nuclease activity (GO:0004518)	0.02960	0.07190	37.53	132.12
14	cytokine receptor activity (GO:0004896)	0.04315	0.09780	25.42	79.89
15	cytokine receptor binding (GO:0005126)	0.05129	0.1090	21.25	63.11
16	nuclear receptor binding (GO:0016922)	0.05842	0.1168	18.55	52.69
17	metal ion binding (GO:0046872)	0.02616	0.06841	9.45	34.45
18	ubiquitin protein ligase activity (GO:0061630)	0.1240	0.2221	8.37	17.46
19	ubiquitin-like protein ligase activity (GO:0061659)	0.1271	0.2221	8.15	16.80
20	ATP binding (GO:0005524)	0.1306	0.2221	7.91	16.09
21	adenyl ribonucleotide binding (GO:0032559)	0.1429	0.2281	7.17	13.95
22	zinc ion binding (GO:0008270)	0.1559	0.2281	6.52	12.12
23	protein serine/threonine kinase activity (GO:0004674)	0.1593	0.2281	6.36	11.69
24	calcium ion binding (GO:0005509)	0.1610	0.2281	6.29	11.49
25	ubiquitin-protein transferase activity (GO:0004842)	0.1796	0.2443	5.57	9.56
26	transition metal ion binding (GO:0046914)	0.2015	0.2526	4.89	7.84
27	purine ribonucleoside triphosphate binding (GO:0035639)	0.2076	0.2526	4.73	7.43
28	kinase binding (GO:0019900)	0.2080	0.2526	4.72	7.41
29	protein homodimerization activity (GO:0042803)	0.2762	0.3238	3.39	4.36
30	sequence-specific DNA binding (GO:0043565)	0.3023	0.3426	3.03	3.63
31	DNA binding (GO:0003677)	0.3390	0.3718	2.63	2.85
32	RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)	0.4467	0.4602	1.82	1.47
33	cis-regulatory region sequence-specific DNA binding (GO:0000987)	0.4467	0.4602	1.82	1.47
34	RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)	0.5053	0.5053	1.52	1.04

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	T cell receptor complex (GO:0042101)	0.00001481	0.0002073	499.50	5554.53
2	CD95 death-inducing signaling complex (GO:0031265)	0.002498	0.009549	555.17	3326.77
3	cytolytic granule (GO:0044194)	0.003495	0.009549	370.07	2093.27
4	death-inducing signaling complex (GO:0031264)	0.003994	0.009549	317.19	1751.86
5	early phagosome (GO:0032009)	0.005985	0.01197	201.81	1032.95
6	membrane raft (GO:0045121)	0.002846	0.009549	30.79	180.49
7	clathrin-coated vesicle (GO:0030136)	0.03930	0.06487	28.00	90.64
8	clathrin-coated endocytic vesicle (GO:0045334)	0.04171	0.06487	26.33	83.66
9	phagocytic vesicle (GO:0045335)	0.04890	0.06846	22.32	67.37
10	integral component of plasma membrane (GO:0005887)	0.004093	0.009549	8.52	46.87
11	endocytic vesicle (GO:0030139)	0.09060	0.1153	11.70	28.10
12	lysosome (GO:0005764)	0.2145	0.2310	4.56	7.01
13	nucleus (GO:0005634)	0.1672	0.1951	2.31	4.13
14	intracellular membrane-bounded organelle (GO:0043231)	0.2469	0.2469	1.90	2.66