Weight loss (HP:0001824)
Reduction of total body weight.
Synonyms: Loss of weight
Cross References: MSH:D015431, SNOMEDCT_US:161832001, SNOMEDCT_US:262285001, SNOMEDCT_US:89362005, UMLS:C1262477
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Fanconi anemia pathway | 8.485e-27 | 4.242e-26 | 199460.00 | 11973883.48 |
| 2 | Homologous recombination | 0.02032 | 0.05079 | 55.42 | 215.92 |
| 3 | Pancreatic cancer | 0.03736 | 0.06227 | 29.50 | 96.98 |
| 4 | Ubiquitin mediated proteolysis | 0.06785 | 0.08481 | 15.87 | 42.69 |
| 5 | Pathways in cancer | 0.2360 | 0.2360 | 4.08 | 5.89 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | interstrand cross-link repair (GO:0036297) | 1.037e-26 | 7.259e-25 | 199450.00 | 11933257.10 |
| 2 | DNA repair (GO:0006281) | 4.636e-19 | 1.623e-17 | 197020.00 | 8317234.26 |
| 3 | double-strand break repair via synthesis-dependent strand annealing (GO:0045003) | 0.000002248 | 0.00003147 | 1665.58 | 21661.60 |
| 4 | positive regulation of protein monoubiquitination (GO:1902527) | 0.002498 | 0.01165 | 555.17 | 3326.77 |
| 5 | positive regulation of DNA ligation (GO:0051106) | 0.002498 | 0.01165 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | DNA polymerase binding (GO:0070182) | 0.00003428 | 0.0006856 | 312.09 | 3208.63 |
| 2 | four-way junction helicase activity (GO:0009378) | 0.002997 | 0.02703 | 444.11 | 2580.41 |
| 3 | 3′-5′ DNA helicase activity (GO:0043138) | 0.007973 | 0.02703 | 147.96 | 714.91 |
| 4 | four-way junction DNA binding (GO:0000400) | 0.008469 | 0.02703 | 138.71 | 661.82 |
| 5 | single-stranded DNA helicase activity (GO:0017116) | 0.009462 | 0.02703 | 123.28 | 574.57 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | condensed chromosome (GO:0000793) | 0.0003175 | 0.001508 | 95.86 | 772.11 |
| 2 | condensed nuclear chromosome (GO:0000794) | 0.009957 | 0.01713 | 116.79 | 538.34 |
| 3 | chromosome (GO:0005694) | 0.002744 | 0.008232 | 31.38 | 185.09 |
| 4 | nuclear lumen (GO:0031981) | 0.0003351 | 0.001508 | 17.32 | 138.56 |
| 5 | nuclear chromosome (GO:0000228) | 0.04074 | 0.04074 | 26.98 | 86.34 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| FANCD2 | DOXORUBICIN HYDROCHLORIDE |
| RAD51 | – |
| FANCM | – |
| FANCA | CISPLATIN |
| FANCC | MITOMYCIN, CHLORAMBUCIL, MELPHALAN |
| FANCL | – |
| FANCG | – |
| UBE2T | – |
| FANCB | – |
| FANCF | – |
