Vitreous floaters (HP:0100832)
Deposits of various size, shape, consistency, refractive index, and motility within the eye’s vitreous humour, which is normally transparent.
Synonyms: Spots in front of eyes, Eye floaters, Flitting flies, Mouches volantes, Myodeopsia, Myodesopsia, Vitreous condensations, Vitreous debris, Vitreous opacities, Vitreous veils
Comment: Vitreous floaters are described as vitreous condensations (or vitreous debris or vitreous opacities) as a finding upon ophthalmological examination. Floaters can take many forms from little dots, circles, lines, to clouds or cobwebs. The floaters are created by a shadow of the floating vitreal debris that is projected onto the retina, which is described as a veil.
Cross References: SNOMEDCT_US:15013002, SNOMEDCT_US:162278001, SNOMEDCT_US:420999000, UMLS:C0016242, UMLS:C1720491
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid cancer | 0.007380 | 0.04977 | 184.81 | 907.25 |
| 2 | Endometrial cancer | 0.01155 | 0.04977 | 116.60 | 520.17 |
| 3 | Basal cell carcinoma | 0.01254 | 0.04977 | 107.17 | 469.28 |
| 4 | Adherens junction | 0.01413 | 0.04977 | 94.89 | 404.19 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy | 0.01531 | 0.04977 | 87.37 | 365.12 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular response to indole-3-methanol (GO:0071681) | 0.0009997 | 0.01417 | 1666.00 | 11508.86 |
| 2 | response to indole-3-methanol (GO:0071680) | 0.0009997 | 0.01417 | 1666.00 | 11508.86 |
| 3 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 0.0009997 | 0.01417 | 1666.00 | 11508.86 |
| 4 | embryonic skeletal joint morphogenesis (GO:0060272) | 0.0009997 | 0.01417 | 1666.00 | 11508.86 |
| 5 | regulation of vasculature development (GO:1901342) | 0.00001051 | 0.001367 | 798.84 | 9157.07 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | histone methyltransferase binding (GO:1990226) | 0.002198 | 0.01998 | 666.20 | 4077.19 |
| 2 | I-SMAD binding (GO:0070411) | 0.002598 | 0.01998 | 555.11 | 3304.67 |
| 3 | Wnt-activated receptor activity (GO:0042813) | 0.002997 | 0.01998 | 475.76 | 2764.28 |
| 4 | frizzled binding (GO:0005109) | 0.006783 | 0.02793 | 201.65 | 1006.89 |
| 5 | estrogen receptor binding (GO:0030331) | 0.006982 | 0.02793 | 195.71 | 971.56 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | beta-catenin-TCF complex (GO:1990907) | 0.002598 | 0.02857 | 555.11 | 3304.67 |
| 2 | catenin complex (GO:0016342) | 0.006186 | 0.03402 | 221.84 | 1128.18 |
| 3 | adherens junction (GO:0005912) | 0.02614 | 0.08212 | 50.55 | 184.21 |
| 4 | basolateral plasma membrane (GO:0016323) | 0.02986 | 0.08212 | 44.10 | 154.85 |
| 5 | cell-cell junction (GO:0005911) | 0.05311 | 0.1052 | 24.35 | 71.48 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NDP | – |
| TSPAN12 | – |
| ZNF408 | – |
| CTNNB1 | FLUORESCEN SODIUM |
