Urinary incontinence (HP:0000020)
Loss of the ability to control the urinary bladder leading to involuntary urination.
Synonyms: Loss of bladder control, Bladder incontinence
Comment: Urinary incontinence can be defined as the complaint of any involuntary leakage of urine.
Pubmed References: PMID:12559262
Cross References: MSH:D014549, SNOMEDCT_US:165232002, UMLS:C0042024
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Arginine and proline metabolism | 0.02473 | 0.09066 | 45.22 | 167.30 |
| 2 | Non-small cell lung cancer | 0.03543 | 0.09743 | 31.17 | 104.12 |
| 3 | Amyotrophic lateral sclerosis | 0.01350 | 0.09066 | 13.56 | 58.36 |
| 4 | Dopaminergic synapse | 0.06409 | 0.1410 | 16.84 | 46.28 |
| 5 | Pathways of neurodegeneration | 0.02233 | 0.09066 | 10.32 | 39.22 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic vesicle transport (GO:0048489) | 0.00001235 | 0.0006999 | 555.03 | 6273.06 |
| 2 | synaptic vesicle localization (GO:0097479) | 0.00001750 | 0.0006999 | 454.07 | 4973.59 |
| 3 | proline biosynthetic process (GO:0006561) | 0.002498 | 0.01711 | 555.17 | 3326.77 |
| 4 | anterograde dendritic transport (GO:0098937) | 0.002498 | 0.01711 | 555.17 | 3326.77 |
| 5 | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) | 0.002498 | 0.01711 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | gap junction channel activity involved in cell communication by electrical coupling (GO:1903763) | 0.002997 | 0.02873 | 444.11 | 2580.41 |
| 2 | outward rectifier potassium channel activity (GO:0015271) | 0.005488 | 0.02873 | 222.00 | 1155.57 |
| 3 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620) | 0.009957 | 0.02873 | 116.79 | 538.34 |
| 4 | gap junction channel activity (GO:0005243) | 0.01194 | 0.02873 | 96.46 | 427.12 |
| 5 | wide pore channel activity (GO:0022829) | 0.01243 | 0.02873 | 92.44 | 405.55 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endoplasmic reticulum tubular network membrane (GO:0098826) | 0.002498 | 0.05861 | 555.17 | 3326.77 |
| 2 | connexin complex (GO:0005922) | 0.01045 | 0.05861 | 110.94 | 506.01 |
| 3 | endoplasmic reticulum tubular network (GO:0071782) | 0.01144 | 0.05861 | 100.85 | 450.83 |
| 4 | gap junction (GO:0005921) | 0.01194 | 0.05861 | 96.46 | 427.12 |
| 5 | Golgi cis cisterna (GO:0000137) | 0.01243 | 0.05861 | 92.44 | 405.55 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KIF5A | – |
| NIPA1 | – |
| KIAA0196 | – |
| SPG11 | – |
| RTN2 | – |
| SPAST | – |
| ATL1 | – |
| GJC2 | CARBENOXOLONE |
| ALDH18A1 | – |
| KCNT1 | CLOFILIUM, LOXAPINE, QUINIDINE |
