Tremor (HP:0001337)
An unintentional, oscillating to-and-fro muscle movement about a joint axis.
Synonyms: Tremor, Tremors
Comment: Tremor is differentiated from other involuntary movement disorders, such as chorea, athetosis, ballism, tics, and myoclonus, by its repetitive, stereotyped movements of a regular amplitude and frequency. Clonus, unlike tremor, represents a rhythmic movement, which is increased by muscle stretching.
Pubmed References: PMID:16344298 , PMID:20589866
Cross References: MSH:D014202, SNOMEDCT_US:26079004, UMLS:C0040822
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ciliary basal body-plasma membrane docking (GO:0097711) | 3.584e-24 | 1.147e-22 | 199050.00 | 10745825.19 |
| 2 | cilium assembly (GO:0060271) | 7.884e-19 | 1.261e-17 | 196860.00 | 8205971.98 |
| 3 | protein localization to ciliary transition zone (GO:1904491) | 0.000003371 | 0.00001541 | 1249.13 | 15739.23 |
| 4 | cilium organization (GO:0044782) | 1.113e-14 | 1.187e-13 | 359.45 | 11549.06 |
| 5 | plasma membrane bounded cell projection assembly (GO:0120031) | 5.535e-14 | 4.428e-13 | 292.15 | 8917.85 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cilium (GO:0005929) | 5.245e-10 | 4.196e-9 | 128.31 | 2741.69 |
| 2 | ciliary membrane (GO:0060170) | 0.0001038 | 0.0004153 | 172.08 | 1578.44 |
| 3 | cell projection membrane (GO:0031253) | 0.0009195 | 0.002452 | 55.28 | 386.48 |
| 4 | motile cilium (GO:0031514) | 0.03349 | 0.05359 | 33.04 | 112.22 |
| 5 | cell-cell junction (GO:0005911) | 0.007662 | 0.01532 | 18.33 | 89.29 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| B9D1 | – |
| CC2D2A | – |
| TCTN2 | – |
| CEP41 | – |
| TCTN3 | – |
| MKS1 | – |
| TMEM216 | – |
| RPGRIP1L | – |
| TCTN1 | – |
| NPHP1 | – |
