Tinnitus (HP:0000360)
Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.
Synonyms: Ringing in ears, Ringing in the ears
Cross References: MSH:D014012, SNOMEDCT_US:162349004, SNOMEDCT_US:162352007, SNOMEDCT_US:60862001, UMLS:C0040264
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Aldosterone synthesis and secretion | 0.00001335 | 0.0007611 | 89.75 | 1007.36 |
| 2 | GnRH secretion | 0.0004462 | 0.008477 | 80.35 | 619.92 |
| 3 | Circadian entrainment | 0.001021 | 0.01456 | 52.36 | 360.55 |
| 4 | Citrate cycle (TCA cycle) | 0.01490 | 0.06534 | 76.48 | 321.69 |
| 5 | Serotonergic synapse | 0.001382 | 0.01576 | 44.77 | 294.78 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of adenylate cyclase activity (GO:0045762) | 0.000004719 | 0.001368 | 999.25 | 12254.80 |
| 2 | positive regulation of cyclase activity (GO:0031281) | 0.00002041 | 0.002276 | 416.21 | 4494.85 |
| 3 | positive regulation of lyase activity (GO:0051349) | 0.00002354 | 0.002276 | 384.17 | 4094.01 |
| 4 | establishment of protein localization to telomere (GO:0070200) | 0.002498 | 0.03750 | 555.17 | 3326.77 |
| 5 | glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860) | 0.002498 | 0.03750 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007) | 0.002498 | 0.03707 | 555.17 | 3326.77 |
| 2 | RNA-directed DNA polymerase activity (GO:0003964) | 0.002997 | 0.03707 | 444.11 | 2580.41 |
| 3 | telomerase activity (GO:0003720) | 0.002997 | 0.03707 | 444.11 | 2580.41 |
| 4 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (GO:0016713) | 0.004492 | 0.03707 | 277.53 | 1500.17 |
| 5 | phosphatidylethanolamine binding (GO:0008429) | 0.004492 | 0.03707 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transferase complex, transferring phosphorus-containing groups (GO:0061695) | 0.004492 | 0.03893 | 277.53 | 1500.17 |
| 2 | MLL1 complex (GO:0071339) | 0.01293 | 0.04003 | 88.73 | 385.85 |
| 3 | MLL1/2 complex (GO:0044665) | 0.01293 | 0.04003 | 88.73 | 385.85 |
| 4 | axon (GO:0030424) | 0.0001190 | 0.003095 | 42.19 | 381.27 |
| 5 | voltage-gated calcium channel complex (GO:0005891) | 0.01540 | 0.04003 | 73.93 | 308.54 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| MAX | – |
| RET | CABOZANTINIB, VANDETANIB |
| KIF1B | – |
| SDHC | – |
| SDHAF2 | – |
| TERT | OMACETAXINE MEPESUCCINATE |
| CACNA1D | ISRADIPINE, CLEVIDIPINE, NIMODIPINE, NITRENDIPINE |
| CYP11B2 | IMADIPRIL, BENAZEPRIL, METOCLOPRAMIDE |
| KCNJ5 | – |
