Temperature instability (HP:0005968)
Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.
Synonyms: Temperature instability, Body temperature instability
Cross References: UMLS:C1820737, UMLS:C3279038
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hedgehog signaling pathway | 0.000002460 | 0.00006643 | 161.22 | 2082.13 |
| 2 | Phenylalanine metabolism | 0.008469 | 0.04573 | 138.71 | 661.82 |
| 3 | Basal cell carcinoma | 0.0004323 | 0.005837 | 81.68 | 632.69 |
| 4 | Tyrosine metabolism | 0.01786 | 0.08026 | 63.35 | 255.00 |
| 5 | Tryptophan metabolism | 0.02081 | 0.08026 | 54.06 | 209.35 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry (GO:1900175) | 0.000002248 | 0.0002038 | 1665.58 | 21661.60 |
| 2 | positive regulation of T cell differentiation in thymus (GO:0033089) | 0.000003371 | 0.0002038 | 1249.13 | 15739.23 |
| 3 | dorsal/ventral pattern formation (GO:0009953) | 3.331e-10 | 8.062e-8 | 665.67 | 14526.48 |
| 4 | pituitary gland development (GO:0021983) | 0.000004719 | 0.0002038 | 999.25 | 12254.80 |
| 5 | proximal/distal pattern formation (GO:0009954) | 0.000006290 | 0.0002174 | 832.67 | 9972.50 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | morphogen activity (GO:0016015) | 0.000004719 | 0.0001274 | 999.25 | 12254.80 |
| 2 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.01686 | 555.17 | 3326.77 |
| 3 | type 2 fibroblast growth factor receptor binding (GO:0005111) | 0.002498 | 0.01686 | 555.17 | 3326.77 |
| 4 | patched binding (GO:0005113) | 0.003495 | 0.01887 | 370.07 | 2093.27 |
| 5 | activin receptor binding (GO:0070697) | 0.004990 | 0.02245 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | U4 snRNP (GO:0005687) | 0.004492 | 0.03319 | 277.53 | 1500.17 |
| 2 | prespliceosome (GO:0071010) | 0.007476 | 0.03319 | 158.54 | 776.21 |
| 3 | U2-type prespliceosome (GO:0071004) | 0.007476 | 0.03319 | 158.54 | 776.21 |
| 4 | U5 snRNP (GO:0005682) | 0.008469 | 0.03319 | 138.71 | 661.82 |
| 5 | U1 snRNP (GO:0005685) | 0.008966 | 0.03319 | 130.54 | 615.43 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ZIC2 | – |
| SIX3 | – |
| SHH | VISMODEGIB, CAFFEINE |
| GLI2 | – |
| FGF8 | – |
| CDON | – |
| NODAL | – |
| SNRPN | – |
| NPAP1 | – |
| DDC | CARBIDOPA, BENSERAZIDE |
