Suicidal ideation (HP:0031589)
Frequent thinking about or preoccupation with killing oneself.
Synonyms: Suicidality
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 0.00008138 | 0.0008138 | 210.05 | 1977.93 |
| 2 | Primary bile acid biosynthesis | 0.005936 | 0.01187 | 208.09 | 1066.85 |
| 3 | Cholinergic synapse | 0.0006523 | 0.002174 | 71.65 | 525.53 |
| 4 | Neuroactive ligand-receptor interaction | 0.0001634 | 0.0008171 | 43.61 | 380.27 |
| 5 | Cholesterol metabolism | 0.01737 | 0.02895 | 67.84 | 274.94 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic transmission, cholinergic (GO:0007271) | 2.538e-8 | 0.000001954 | 936.42 | 16377.54 |
| 2 | response to acetylcholine (GO:1905144) | 0.001749 | 0.006733 | 832.88 | 5287.72 |
| 3 | response to cocaine (GO:0042220) | 0.001749 | 0.006733 | 832.88 | 5287.72 |
| 4 | vitamin D3 metabolic process (GO:0070640) | 0.001749 | 0.006733 | 832.88 | 5287.72 |
| 5 | sensory perception of pain (GO:0019233) | 0.00002198 | 0.0002821 | 420.51 | 4510.07 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | acetylcholine-gated cation-selective channel activity (GO:0022848) | 4.326e-9 | 8.219e-8 | 1873.59 | 36082.86 |
| 2 | excitatory extracellular ligand-gated ion channel activity (GO:0005231) | 3.482e-8 | 1.915e-7 | 832.29 | 14293.04 |
| 3 | postsynaptic neurotransmitter receptor activity (GO:0098960) | 3.482e-8 | 1.915e-7 | 832.29 | 14293.04 |
| 4 | acetylcholine receptor activity (GO:0015464) | 4.031e-8 | 1.915e-7 | 788.45 | 13424.62 |
| 5 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) | 1.061e-7 | 4.034e-7 | 554.61 | 8906.19 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | acetylcholine-gated channel complex (GO:0005892) | 9.539e-9 | 2.003e-7 | 1362.41 | 25160.79 |
| 2 | ion channel complex (GO:0034702) | 1.710e-7 | 0.000001795 | 467.84 | 7289.66 |
| 3 | catenin complex (GO:0016342) | 0.01080 | 0.04536 | 110.91 | 502.19 |
| 4 | neuron projection (GO:0043005) | 0.0006880 | 0.004816 | 26.37 | 191.99 |
| 5 | late endosome membrane (GO:0031902) | 0.02356 | 0.07443 | 49.57 | 185.78 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KCNT1 | CLOFILIUM, LOXAPINE, QUINIDINE |
| CHRNB2 | NICOTINE, VARENICLINE, VARENICLINE TARTRATE, NICOTINE POLACRILEX |
| CHRNA4 | VARENICLINE |
| CHRNA2 | PIPECURONIUM, METOCURINE, CISATRACURIUM, PANCURONIUM, MECAMYLAMINE, DOXACURIUM, MIVACURIUM, DECAMETHONIUM, VECURONIUM, TUBOCURARINE |
| CYP27A1 | CHOLESTYRAMINE |
| FIG4 | – |
| CDH23 | METHYLPHENIDATE |
