Slurred speech (HP:0001350)
Abnormal coordination of muscles involved in speech.
Synonyms: Slurred speech
Cross References: SNOMEDCT_US:289195008, UMLS:C0234518
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary bile acid biosynthesis | 0.008469 | 0.07480 | 138.71 | 661.82 |
| 2 | Spinocerebellar ataxia | 0.00004140 | 0.001118 | 60.77 | 613.26 |
| 3 | Nicotine addiction | 0.01983 | 0.08190 | 56.84 | 222.86 |
| 4 | Cocaine addiction | 0.02424 | 0.08190 | 46.16 | 171.72 |
| 5 | Notch signaling pathway | 0.02912 | 0.08190 | 38.18 | 135.03 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | negative regulation of tubulin deacetylation (GO:1904428) | 0.002498 | 0.02880 | 555.17 | 3326.77 |
| 2 | positive regulation of protein localization to synapse (GO:1902474) | 0.002498 | 0.02880 | 555.17 | 3326.77 |
| 3 | cellular response to brain-derived neurotrophic factor stimulus (GO:1990416) | 0.002498 | 0.02880 | 555.17 | 3326.77 |
| 4 | intracellular distribution of mitochondria (GO:0048312) | 0.002498 | 0.02880 | 555.17 | 3326.77 |
| 5 | regulation of ribonucleoprotein complex localization (GO:2000197) | 0.002997 | 0.02880 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glutamate-gated calcium ion channel activity (GO:0022849) | 0.002498 | 0.02618 | 555.17 | 3326.77 |
| 2 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634) | 0.003495 | 0.02618 | 370.07 | 2093.27 |
| 3 | minor groove of adenine-thymine-rich DNA binding (GO:0003680) | 0.003495 | 0.02618 | 370.07 | 2093.27 |
| 4 | acyl-CoA oxidase activity (GO:0003997) | 0.003495 | 0.02618 | 370.07 | 2093.27 |
| 5 | poly(G) binding (GO:0034046) | 0.003994 | 0.02618 | 317.19 | 1751.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurofibrillary tangle (GO:0097418) | 0.002498 | 0.01648 | 555.17 | 3326.77 |
| 2 | NMDA selective glutamate receptor complex (GO:0017146) | 0.003994 | 0.02197 | 317.19 | 1751.86 |
| 3 | nuclear inclusion body (GO:0042405) | 0.005488 | 0.02587 | 222.00 | 1155.57 |
| 4 | glial cell projection (GO:0097386) | 0.006979 | 0.02789 | 170.74 | 847.70 |
| 5 | asymmetric synapse (GO:0032279) | 0.00003334 | 0.0006142 | 65.47 | 674.94 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MAPT | – |
| KCNA1 | BUPIVACAINE, ISOFLURANE, DESFLURANE |
| MOG | – |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| DNAJC6 | – |
| KCND3 | – |
| ATXN1 | – |
| SETD2 | – |
| ACOX2 | – |
| HCRT | – |
