Seizure (HP:0001250)
A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.
Synonyms: Seizures, Seizures, Epilepsy, Epileptic seizure
Comment: A type of electrographic seizure has been proposed in neonates which does not have a clinical correlate, it is electrographic only. The term epilepsy is not used to describe recurrent febrile seizures. Epilepsy presumably reflects an abnormally reduced seizure threshold.
Pubmed References: PMID:15816939
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cilium assembly (GO:0060271) | 7.884e-19 | 1.419e-17 | 196860.00 | 8205971.98 |
| 2 | ciliary basal body-plasma membrane docking (GO:0097711) | 8.554e-18 | 7.699e-17 | 915.08 | 35962.78 |
| 3 | cilium organization (GO:0044782) | 2.747e-17 | 1.648e-16 | 812.51 | 30983.64 |
| 4 | plasma membrane bounded cell projection assembly (GO:0120031) | 1.681e-16 | 7.564e-16 | 659.81 | 23965.68 |
| 5 | protein localization to ciliary transition zone (GO:1904491) | 0.000003371 | 0.000008669 | 1249.13 | 15739.23 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | gamma-tubulin binding (GO:0043015) | 0.01144 | 0.02289 | 100.85 | 450.83 |
| 2 | tubulin binding (GO:0015631) | 0.1433 | 0.1433 | 7.15 | 13.88 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ciliary membrane (GO:0060170) | 0.0001038 | 0.0002595 | 172.08 | 1578.44 |
| 2 | cilium (GO:0005929) | 5.378e-8 | 2.689e-7 | 85.16 | 1425.50 |
| 3 | cell projection membrane (GO:0031253) | 0.0009195 | 0.001533 | 55.28 | 386.48 |
| 4 | bounding membrane of organelle (GO:0098588) | 0.05389 | 0.06736 | 6.28 | 18.35 |
| 5 | cell-cell junction (GO:0005911) | 0.1276 | 0.1276 | 8.12 | 16.71 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CC2D2A | – |
| B9D1 | – |
| TCTN2 | – |
| TMEM231 | – |
| TMEM216 | – |
| B9D2 | – |
| MKS1 | – |
| RPGRIP1L | – |
| TCTN1 | – |
| TMEM138 | – |
