Rigidity (HP:0002063)
Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.
Synonyms: Muscle rigidity, Rigidity
Comment: Rigidity is often a manifestation of basal ganglia diseases.
Cross References: MSH:D009127, SNOMEDCT_US:16046003, UMLS:C0026837
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Taste transduction | 0.0008042 | 0.01608 | 59.24 | 422.16 |
| 2 | Dopaminergic synapse | 0.001879 | 0.01879 | 38.19 | 239.73 |
| 3 | Nicotine addiction | 0.01983 | 0.1070 | 56.84 | 222.86 |
| 4 | Type II diabetes mellitus | 0.02277 | 0.1070 | 49.25 | 186.27 |
| 5 | Cortisol synthesis and secretion | 0.03204 | 0.1070 | 34.59 | 119.03 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization (GO:0051899) | 2.132e-15 | 1.034e-13 | 1151.77 | 38908.86 |
| 2 | neuronal action potential (GO:0019228) | 2.480e-13 | 6.014e-12 | 1174.88 | 34101.37 |
| 3 | membrane depolarization during action potential (GO:0086010) | 6.190e-13 | 1.001e-11 | 950.90 | 26730.60 |
| 4 | inorganic cation transmembrane transport (GO:0098662) | 1.473e-16 | 1.429e-14 | 669.91 | 24420.91 |
| 5 | action potential (GO:0001508) | 1.912e-14 | 6.182e-13 | 767.35 | 24238.98 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 2.480e-13 | 4.960e-12 | 1174.88 | 34101.37 |
| 2 | sodium channel activity (GO:0005272) | 4.712e-12 | 4.712e-11 | 604.76 | 15772.67 |
| 3 | voltage-gated cation channel activity (GO:0022843) | 5.976e-10 | 3.984e-9 | 216.28 | 4593.43 |
| 4 | delayed rectifier potassium channel activity (GO:0005251) | 4.872e-7 | 0.000001624 | 285.14 | 4144.43 |
| 5 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) | 0.002498 | 0.007136 | 555.17 | 3326.77 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 5.833e-14 | 8.167e-13 | 1664.83 | 50731.79 |
| 2 | sodium channel complex (GO:0034706) | 5.000e-13 | 3.500e-12 | 998.50 | 28281.59 |
| 3 | axon (GO:0030424) | 1.211e-12 | 5.652e-12 | 234.43 | 6432.76 |
| 4 | voltage-gated potassium channel complex (GO:0008076) | 3.373e-8 | 7.870e-8 | 192.47 | 3311.50 |
| 5 | potassium channel complex (GO:0034705) | 4.893e-8 | 9.785e-8 | 174.68 | 2940.45 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN1A | ETHOSUXIMIDE |
| SCN2A | – |
| KCNA2 | – |
| SCN8A | – |
| SCN9A | – |
| KCND3 | – |
| KCNA4 | – |
| SCN1B | ZONISAMIDE |
| KCNB1 | – |
| CACNA1B | ZICONOTIDE, ZICONOTIDE ACETATE, AMLODIPINE, LEVETIRACETAM |
