Restless legs (HP:0012452)
A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia).
Synonyms: Willis-Ekbom disease, Restless legs syndrome, Wittmaack-Ekbom syndrome
Comment: Restless legs syndrome is a disorder characterized by aching or burning sensations in the legs that occur prior to sleep or may awaken the affected persons. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence.
Cross References: MSH:D012148, SNOMEDCT_US:32914008, UMLS:C0035258
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Pathways of neurodegeneration | 0.0001285 | 0.0007708 | 62.04 | 555.90 |
| 2 | Parkinson disease | 0.001506 | 0.004518 | 53.30 | 346.36 |
| 3 | Mitophagy | 0.01689 | 0.03377 | 74.36 | 303.47 |
| 4 | NOD-like receptor signaling pathway | 0.04444 | 0.06666 | 27.52 | 85.69 |
| 5 | Endocytosis | 0.06144 | 0.07373 | 19.67 | 54.86 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of vascular associated smooth muscle cell apoptotic process (GO:1905461) | 0.001249 | 0.01820 | 1249.44 | 8352.53 |
| 2 | regulation of vascular associated smooth muscle cell apoptotic process (GO:1905459) | 0.001749 | 0.01820 | 832.88 | 5287.72 |
| 3 | positive regulation of mitophagy in response to mitochondrial depolarization (GO:0098779) | 0.001749 | 0.01820 | 832.88 | 5287.72 |
| 4 | intermediate filament bundle assembly (GO:0045110) | 0.001749 | 0.01820 | 832.88 | 5287.72 |
| 5 | positive regulation of smooth muscle cell apoptotic process (GO:0034393) | 0.002248 | 0.01893 | 624.59 | 3808.55 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | alpha-2A adrenergic receptor binding (GO:0031694) | 0.001249 | 0.008347 | 1249.44 | 8352.53 |
| 2 | adrenergic receptor binding (GO:0031690) | 0.004243 | 0.01379 | 312.17 | 1705.22 |
| 3 | ubiquitin protein ligase binding (GO:0031625) | 0.001703 | 0.008347 | 50.02 | 318.87 |
| 4 | ubiquitin-like protein ligase binding (GO:0044389) | 0.001926 | 0.008347 | 46.94 | 293.48 |
| 5 | ubiquitin binding (GO:0043130) | 0.01837 | 0.03632 | 68.23 | 272.72 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intrinsic component of mitochondrial membrane (GO:0098573) | 0.002997 | 0.04016 | 454.18 | 2638.91 |
| 2 | intrinsic component of mitochondrial outer membrane (GO:0031306) | 0.005737 | 0.04016 | 226.97 | 1171.32 |
| 3 | mitochondrial outer membrane (GO:0005741) | 0.03111 | 0.08167 | 39.74 | 137.91 |
| 4 | asymmetric synapse (GO:0032279) | 0.03281 | 0.08167 | 37.62 | 128.54 |
| 5 | postsynaptic density (GO:0014069) | 0.03403 | 0.08167 | 36.24 | 122.50 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NEFL | – |
| UCHL1 | – |
| MFN2 | – |
| DNAJC6 | – |
| ATXN7 | – |
