Renal insufficiency (HP:0000083)
A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.
Synonyms: Renal failure, Renal failure in adulthood
Cross References: MSH:D051437, SNOMEDCT_US:236423003, SNOMEDCT_US:42399005, UMLS:C0035078, UMLS:C1565489, UMLS:C1839604
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Fanconi anemia pathway | 8.485e-27 | 3.394e-26 | 199460.00 | 11973883.48 |
| 2 | Homologous recombination | 0.02032 | 0.04063 | 55.42 | 215.92 |
| 3 | Pancreatic cancer | 0.03736 | 0.04982 | 29.50 | 96.98 |
| 4 | Pathways in cancer | 0.2360 | 0.2360 | 4.08 | 5.89 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | interstrand cross-link repair (GO:0036297) | 1.037e-26 | 7.674e-25 | 199450.00 | 11933257.10 |
| 2 | DNA repair (GO:0006281) | 4.636e-19 | 1.715e-17 | 197020.00 | 8317234.26 |
| 3 | double-strand break repair via synthesis-dependent strand annealing (GO:0045003) | 0.000002248 | 0.00002773 | 1665.58 | 21661.60 |
| 4 | resolution of meiotic recombination intermediates (GO:0000712) | 0.00002690 | 0.0002844 | 356.71 | 3753.85 |
| 5 | positive regulation of protein monoubiquitination (GO:1902527) | 0.002498 | 0.009641 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | DNA polymerase binding (GO:0070182) | 0.00003428 | 0.0006170 | 312.09 | 3208.63 |
| 2 | four-way junction helicase activity (GO:0009378) | 0.002997 | 0.01348 | 444.11 | 2580.41 |
| 3 | crossover junction endodeoxyribonuclease activity (GO:0008821) | 0.002997 | 0.01348 | 444.11 | 2580.41 |
| 4 | 5′-flap endonuclease activity (GO:0017108) | 0.003994 | 0.01348 | 317.19 | 1751.86 |
| 5 | endodeoxyribonuclease activity, producing 3′-phosphomonoesters (GO:0016889) | 0.004492 | 0.01348 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | condensed chromosome (GO:0000793) | 0.0003175 | 0.002858 | 95.86 | 772.11 |
| 2 | condensed nuclear chromosome (GO:0000794) | 0.009957 | 0.02240 | 116.79 | 538.34 |
| 3 | chromosome (GO:0005694) | 0.002744 | 0.01235 | 31.38 | 185.09 |
| 4 | nuclear chromosome (GO:0000228) | 0.04074 | 0.06623 | 26.98 | 86.34 |
| 5 | nuclear lumen (GO:0031981) | 0.005076 | 0.01523 | 11.12 | 58.74 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RAD51 | – |
| FANCM | – |
| FANCD2 | DOXORUBICIN HYDROCHLORIDE |
| FANCA | CISPLATIN |
| FANCB | – |
| SLX4 | – |
| FANCE | – |
| FANCC | MITOMYCIN, CHLORAMBUCIL, MELPHALAN |
| FANCF | – |
| FANCG | – |
