Reduced forced vital capacity (HP:0032341)
An abnormal reduction in the amount of air a person can expel following maximal inspiration.
Synonyms: Reduced FVC, Decreased forced vital capacity
Comment: The threshold for an abnormally low FVC is defined as less than the LLN for adults or less than 80 percent of predicted for those five to 18 years of age, indicating a restrictive pattern. The LLLN (lower limit of normal) is a measurement less than the fifth percentile of spirometry data obtained from the Third National Health and Nutrition Examination Survey (NHANES III).
Pubmed References: PMID:22347750 , PMID:24695507
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Terpenoid backbone biosynthesis | 0.01095 | 0.02098 | 105.66 | 476.99 |
| 2 | Mannose type O-glycan biosynthesis | 0.01144 | 0.02098 | 100.85 | 450.83 |
| 3 | Cardiac muscle contraction | 0.0008229 | 0.003669 | 58.54 | 415.82 |
| 4 | Hypertrophic cardiomyopathy | 0.0008802 | 0.003669 | 56.54 | 397.78 |
| 5 | Dilated cardiomyopathy | 0.001001 | 0.003669 | 52.91 | 365.49 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | actin-myosin filament sliding (GO:0033275) | 7.523e-7 | 0.00004251 | 244.35 | 3445.31 |
| 2 | muscle filament sliding (GO:0030049) | 7.523e-7 | 0.00004251 | 244.35 | 3445.31 |
| 3 | centriole assembly (GO:0098534) | 0.002498 | 0.03382 | 555.17 | 3326.77 |
| 4 | skeletal muscle thin filament assembly (GO:0030240) | 0.002997 | 0.03382 | 444.11 | 2580.41 |
| 5 | regulation of t-circle formation (GO:1904429) | 0.002997 | 0.03382 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533) | 0.002498 | 0.02905 | 555.17 | 3326.77 |
| 2 | prenyltransferase activity (GO:0004659) | 0.004492 | 0.02905 | 277.53 | 1500.17 |
| 3 | DNA polymerase binding (GO:0070182) | 0.008966 | 0.02905 | 130.54 | 615.43 |
| 4 | ADP binding (GO:0043531) | 0.01342 | 0.03088 | 85.32 | 367.79 |
| 5 | dicarboxylic acid transmembrane transporter activity (GO:0005310) | 0.01441 | 0.03088 | 79.21 | 335.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin filament (GO:0032982) | 0.002997 | 0.04064 | 444.11 | 2580.41 |
| 2 | muscle myosin complex (GO:0005859) | 0.007476 | 0.04064 | 158.54 | 776.21 |
| 3 | dense core granule (GO:0031045) | 0.007973 | 0.04064 | 147.96 | 714.91 |
| 4 | supramolecular fiber (GO:0099512) | 0.009462 | 0.04064 | 123.28 | 574.57 |
| 5 | actin filament (GO:0005884) | 0.0005645 | 0.01693 | 71.14 | 532.12 |
Hub genes predicted as biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MYH7 | – |
| ACTA1 | – |
| UNC45B | – |
| TPM3 | CORTICOTROPIN |
| FKRP | – |
| SLC25A21 | – |
| MCIDAS | – |
| GGPS1 | ZOLEDRONIC ACID |
| RTEL1 | – |
| SYT2 | – |
