Reduced forced expiratory volume in one second (HP:0032342)
An abnormal reduction in the amount of air a person can forcefully expel in one second.
Synonyms: Reduced FEV1
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Homologous recombination | 0.0001826 | 0.0009526 | 127.89 | 1100.92 |
| 2 | Fanconi anemia pathway | 0.0003175 | 0.0009526 | 95.86 | 772.11 |
| 3 | Mismatch repair | 0.01144 | 0.02289 | 100.85 | 450.83 |
| 4 | DNA replication | 0.01786 | 0.02679 | 63.35 | 255.00 |
| 5 | Pancreatic cancer | 0.03736 | 0.04484 | 29.50 | 96.98 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | formation of extrachromosomal circular DNA (GO:0001325) | 4.360e-15 | 2.151e-13 | 3330.67 | 110132.57 |
| 2 | t-circle formation (GO:0090656) | 4.360e-15 | 2.151e-13 | 3330.67 | 110132.57 |
| 3 | telomere maintenance via telomere trimming (GO:0090737) | 4.360e-15 | 2.151e-13 | 3330.67 | 110132.57 |
| 4 | telomeric loop disassembly (GO:0090657) | 6.605e-12 | 1.086e-10 | 2220.44 | 57161.21 |
| 5 | G-quadruplex DNA unwinding (GO:0044806) | 3.147e-9 | 2.911e-8 | 2141.36 | 41921.23 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | D-loop DNA binding (GO:0062037) | 0.000002248 | 0.00002473 | 1665.58 | 21661.60 |
| 2 | Y-form DNA binding (GO:0000403) | 0.000002248 | 0.00002473 | 1665.58 | 21661.60 |
| 3 | four-way junction helicase activity (GO:0009378) | 0.000003371 | 0.00002649 | 1249.13 | 15739.23 |
| 4 | 5′-3′ DNA helicase activity (GO:0043139) | 0.000004719 | 0.00003244 | 999.25 | 12254.80 |
| 5 | 5′-flap endonuclease activity (GO:0017108) | 0.000006290 | 0.00003459 | 832.67 | 9972.50 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | shelterin complex (GO:0070187) | 0.002997 | 0.005565 | 444.11 | 2580.41 |
| 2 | transcription factor TFIIH holo complex (GO:0005675) | 0.005985 | 0.008645 | 201.81 | 1032.95 |
| 3 | condensed nuclear chromosome (GO:0000794) | 0.009957 | 0.01294 | 116.79 | 538.34 |
| 4 | chromosome (GO:0005694) | 0.00005786 | 0.0007522 | 54.14 | 528.26 |
| 5 | nuclear chromosome (GO:0000228) | 0.0007493 | 0.001948 | 61.45 | 442.20 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RTEL1 | – |
| DNA2 | – |
| WRN | – |
| RAD51 | – |
| PIF1 | – |
| BLM | – |
| EXO1 | CAPECITABINE |
| TERF1 | – |
| MMS19 | – |
| FAM96B | – |
