Pulmonary embolism (HP:0002204)
An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.
Synonyms: Blood clot in artery of lung
Cross References: MSH:D011655, SNOMEDCT_US:59282003, UMLS:C0034065
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | GnRH secretion | 0.0004462 | 0.01795 | 80.35 | 619.92 |
| 2 | Vitamin digestion and absorption | 0.01194 | 0.07705 | 96.46 | 427.12 |
| 3 | Circadian entrainment | 0.001021 | 0.01795 | 52.36 | 360.55 |
| 4 | Aldosterone synthesis and secretion | 0.001042 | 0.01795 | 51.81 | 355.72 |
| 5 | Serotonergic synapse | 0.001382 | 0.01795 | 44.77 | 294.78 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of cell proliferation involved in heart morphogenesis (GO:2000138) | 0.002498 | 0.02379 | 555.17 | 3326.77 |
| 2 | atrial cardiac muscle cell membrane repolarization (GO:0099624) | 0.002498 | 0.02379 | 555.17 | 3326.77 |
| 3 | membrane repolarization during atrial cardiac muscle cell action potential (GO:0098914) | 0.002498 | 0.02379 | 555.17 | 3326.77 |
| 4 | transsulfuration (GO:0019346) | 0.002498 | 0.02379 | 555.17 | 3326.77 |
| 5 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.002498 | 0.02379 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor (GO:0016723) | 0.002498 | 0.03991 | 555.17 | 3326.77 |
| 2 | U2 snRNA binding (GO:0030620) | 0.002498 | 0.03991 | 555.17 | 3326.77 |
| 3 | G protein-coupled serotonin receptor binding (GO:0031821) | 0.002997 | 0.03991 | 444.11 | 2580.41 |
| 4 | U1 snRNA binding (GO:0030619) | 0.003994 | 0.03991 | 317.19 | 1751.86 |
| 5 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) | 0.005985 | 0.03991 | 201.81 | 1032.95 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | heterotrimeric G-protein complex (GO:0005834) | 0.01638 | 0.1572 | 69.30 | 284.93 |
| 2 | voltage-gated potassium channel complex (GO:0008076) | 0.03591 | 0.1572 | 30.74 | 102.25 |
| 3 | potassium channel complex (GO:0034705) | 0.03930 | 0.1572 | 28.00 | 90.64 |
| 4 | lytic vacuole membrane (GO:0098852) | 0.1258 | 0.3344 | 8.24 | 17.08 |
| 5 | lysosomal membrane (GO:0005765) | 0.1533 | 0.3344 | 6.64 | 12.45 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SMAD4 | LYSINE, ALECTINIB |
| GDF2 | – |
| GNAQ | VERTEPORFIN |
| CBSL | – |
| ENSP00000381231 | – |
| COIL | – |
| TGS1 | – |
| MMACHC | – |
| MEFV | – |
| KCNJ5 | – |
