Pleuritis (HP:0002102)
Inflammation of the pleura.
Synonyms: Inflammation of tissues lining lungs and chest, Pleurisy
Cross References: MSH:D010998, SNOMEDCT_US:196075003, UMLS:C0032231
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Autoimmune thyroid disease | 0.0001435 | 0.006456 | 156.41 | 1384.12 |
| 2 | African trypanosomiasis | 0.01288 | 0.08302 | 92.39 | 402.10 |
| 3 | Measles | 0.0009843 | 0.02215 | 57.97 | 401.38 |
| 4 | Allograft rejection | 0.01323 | 0.08302 | 89.89 | 388.83 |
| 5 | Graft-versus-host disease | 0.01461 | 0.08302 | 81.11 | 342.76 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of natural killer cell proliferation (GO:0032817) | 0.000002203 | 0.0002108 | 1599.04 | 20828.53 |
| 2 | negative regulation of B cell proliferation (GO:0030889) | 0.000006918 | 0.0004964 | 799.32 | 9496.99 |
| 3 | negative regulation of interleukin-10 production (GO:0032693) | 0.00001424 | 0.0008176 | 532.75 | 5945.01 |
| 4 | positive regulation of natural killer cell proliferation (GO:0032819) | 0.001749 | 0.01195 | 832.88 | 5287.72 |
| 5 | positive regulation of cell fate commitment (GO:0010455) | 0.001749 | 0.01195 | 832.88 | 5287.72 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | IgG binding (GO:0019864) | 0.001749 | 0.01444 | 832.88 | 5287.72 |
| 2 | interleukin-12 receptor binding (GO:0005143) | 0.002098 | 0.01444 | 666.27 | 4108.59 |
| 3 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002098 | 0.01444 | 666.27 | 4108.59 |
| 4 | MutLalpha complex binding (GO:0032405) | 0.002448 | 0.01444 | 555.19 | 3338.15 |
| 5 | MutSalpha complex binding (GO:0032407) | 0.002448 | 0.01444 | 555.19 | 3338.15 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | CD95 death-inducing signaling complex (GO:0031265) | 0.001749 | 0.01538 | 832.88 | 5287.72 |
| 2 | death-inducing signaling complex (GO:0031264) | 0.002797 | 0.01538 | 475.86 | 2797.66 |
| 3 | cytoplasmic side of plasma membrane (GO:0009898) | 0.01909 | 0.05251 | 61.54 | 243.60 |
| 4 | clathrin-coated vesicle (GO:0030136) | 0.02767 | 0.05386 | 42.01 | 150.72 |
| 5 | clathrin-coated endocytic vesicle (GO:0045334) | 0.02938 | 0.05386 | 39.50 | 139.34 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| PTPN22 | – |
| FCGR2B | – |
| IL23R | – |
| FAS | TENIPOSIDE |
| MEFV | – |
| TREX1 | – |
