Hemoptysis (HP:0002105)
Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.
Synonyms: Haemoptysis, Coughing up blood or blood-stained mucus, Coughing up blood
Cross References: MSH:D006469, SNOMEDCT_US:66857006, SNOMEDCT_US:6686005, UMLS:C0019079
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Protein digestion and absorption | 0.00001551 | 0.0004031 | 85.24 | 944.01 |
| 2 | Inflammatory bowel disease | 0.0004602 | 0.003988 | 79.08 | 607.60 |
| 3 | IL-17 signaling pathway | 0.0009597 | 0.006199 | 54.07 | 375.73 |
| 4 | Th17 cell differentiation | 0.001241 | 0.006199 | 47.35 | 316.84 |
| 5 | Platelet activation | 0.001661 | 0.006199 | 40.71 | 260.58 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular response to interleukin-17 (GO:0097398) | 0.000008085 | 0.0003319 | 713.68 | 8368.26 |
| 2 | interleukin-17-mediated signaling pathway (GO:0097400) | 0.000008085 | 0.0003319 | 713.68 | 8368.26 |
| 3 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 0.00002690 | 0.0007666 | 356.71 | 3753.85 |
| 4 | positive regulation of natural killer cell proliferation (GO:0032819) | 0.002498 | 0.02134 | 555.17 | 3326.77 |
| 5 | positive regulation of cell fate commitment (GO:0010455) | 0.002498 | 0.02134 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cyclic nucleotide-dependent protein kinase activity (GO:0004690) | 0.002997 | 0.01398 | 444.11 | 2580.41 |
| 2 | interleukin-12 receptor binding (GO:0005143) | 0.002997 | 0.01398 | 444.11 | 2580.41 |
| 3 | interleukin-17 receptor activity (GO:0030368) | 0.003994 | 0.01398 | 317.19 | 1751.86 |
| 4 | platelet-derived growth factor binding (GO:0048407) | 0.005488 | 0.01537 | 222.00 | 1155.57 |
| 5 | cytokine receptor activity (GO:0004896) | 0.0008418 | 0.01179 | 57.86 | 409.65 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | elastic fiber (GO:0071953) | 0.002498 | 0.009991 | 555.17 | 3326.77 |
| 2 | supramolecular fiber (GO:0099512) | 0.00003830 | 0.0002298 | 293.72 | 2987.15 |
| 3 | microfibril (GO:0001527) | 0.005488 | 0.01646 | 222.00 | 1155.57 |
| 4 | collagen-containing extracellular matrix (GO:0062023) | 0.00002461 | 0.0002298 | 34.78 | 369.07 |
| 5 | filopodium (GO:0030175) | 0.02863 | 0.05005 | 38.86 | 138.07 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ACTA2 | – |
| COL3A1 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| MFAP5 | – |
| COL5A2 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| ELN | – |
| IL23R | – |
| IL17F | – |
| IL17RA | BRODALUMAB |
| PRKG1 | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
