Long COVID-Pulmonary symptom-Airway obstruction – LCGAR: Long COVID Gene Association Resource

Airway obstruction HP:0006536

Obstruction of conducting airways of the lung.

Synonyms: Obstructive lung disease, Pulmonary obstruction

Cross References: MSH:D008173, UMLS:C0600260

KEGG Pathway

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	Huntington disease	0.1429	0.2137	7.17	13.95
2	Amyotrophic lateral sclerosis	0.1678	0.2137	6.01	10.72
3	Pathways of neurodegeneration	0.2137	0.2137	4.57	7.06

GO:Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	axoneme assembly (GO:0035082)	3.163e-15	9.488e-14	1069.39	35704.16
2	axonemal dynein complex assembly (GO:0070286)	1.125e-9	1.688e-8	475.29	9793.38
3	regulation of cilium movement (GO:0003352)	0.00001010	0.00004330	624.44	7182.69
4	cilium-dependent cell motility (GO:0060285)	1.586e-7	0.000001189	427.93	6700.13
5	regulation of microtubule-based movement (GO:0060632)	0.00001235	0.00004629	555.03	6273.06

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	microtubule motor activity (GO:0003777)	0.02766	0.04878	40.27	144.50
2	motor activity (GO:0003774)	0.03252	0.04878	34.06	116.68
3	protein homodimerization activity (GO:0042803)	0.2762	0.2762	3.39	4.36

GO: Cellular Component

Hub genes & FDA drug repurposed