Reticular pattern on pulmonary HRCT (HP:0025390)
On pulmonary high-resolution computed tomography, reticular pattern is characterised by innumerable interlacing shadows suggesting a mesh.
Synonyms: No synonyms found for this term.
Comment: The constituents of the reticular pattern may be all or some of the following: interlobular septal thickening, intralobular interstitial thickening, wall cysts of honeycombing, peribronchovascular interstitial thickening and traction bronchiectasis/bronchiolectasis
Pubmed References: PMID:23247773
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ABC transporters | 0.01343 | 0.06259 | 90.68 | 390.89 |
| 2 | Arrhythmogenic right ventricular cardiomyopathy | 0.02288 | 0.06259 | 52.42 | 198.00 |
| 3 | RNA degradation | 0.02347 | 0.06259 | 51.07 | 191.60 |
| 4 | Gastric cancer | 0.04388 | 0.07897 | 26.82 | 83.84 |
| 5 | Hepatocellular carcinoma | 0.04936 | 0.07897 | 23.74 | 71.44 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of chromosome organization (GO:2001252) | 0.000007861 | 0.001019 | 768.50 | 9032.62 |
| 2 | regulation of telomere maintenance via telomere lengthening (GO:1904356) | 0.00001145 | 0.001019 | 624.31 | 7103.11 |
| 3 | establishment of protein localization to telomere (GO:0070200) | 0.001499 | 0.01519 | 999.50 | 6499.56 |
| 4 | positive regulation of cardioblast differentiation (GO:0051891) | 0.001499 | 0.01519 | 999.50 | 6499.56 |
| 5 | regulation of cardioblast differentiation (GO:0051890) | 0.001499 | 0.01519 | 999.50 | 6499.56 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylcholine flippase activity (GO:0140345) | 0.001499 | 0.01079 | 999.50 | 6499.56 |
| 2 | phosphatidylcholine transfer activity (GO:0120019) | 0.001499 | 0.01079 | 999.50 | 6499.56 |
| 3 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083) | 0.001499 | 0.01079 | 999.50 | 6499.56 |
| 4 | telomerase RNA binding (GO:0070034) | 0.00001728 | 0.0008294 | 499.35 | 5475.89 |
| 5 | RNA-directed DNA polymerase activity (GO:0003964) | 0.001799 | 0.01079 | 799.56 | 5053.71 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | alveolar lamellar body (GO:0097208) | 0.001799 | 0.02254 | 799.56 | 5053.71 |
| 2 | transferase complex, transferring phosphorus-containing groups (GO:0061695) | 0.002697 | 0.02254 | 499.65 | 2955.69 |
| 3 | lamellar body (GO:0042599) | 0.003894 | 0.02434 | 333.03 | 1847.77 |
| 4 | intercalated disc (GO:0014704) | 0.009265 | 0.03860 | 133.09 | 623.08 |
| 5 | cornified envelope (GO:0001533) | 0.01283 | 0.04141 | 95.01 | 413.84 |
Hub genes predicted as biomarkers & predicted approved FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TERT | OMACETAXINE MEPESUCCINATE |
| OBFC1 | ATENOLOL |
| RTEL1 | – |
| DHX36 | – |
| ABCA3 | – |
| DSP | ENALAPRIL |
