Pulmonary fibrosis (HP:0002206)
Replacement of normal lung tissues by fibroblasts and collagen.
Synonyms: No synonyms found for this term.
Comment: Pulmonary fibrosis leads to an irreversible impairment of alveolar oxygen transfer.
Cross References: MSH:D011658, SNOMEDCT_US:51615001, UMLS:C0034069
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Autoimmune thyroid disease | 0.000002081 | 0.0001103 | 170.91 | 2236.02 |
| 2 | Allograft rejection | 0.0001567 | 0.002663 | 138.57 | 1214.06 |
| 3 | Graft-versus-host disease | 0.0001917 | 0.002663 | 124.69 | 1067.29 |
| 4 | Type I diabetes mellitus | 0.0002010 | 0.002663 | 121.64 | 1035.45 |
| 5 | Rheumatoid arthritis | 0.0009395 | 0.009959 | 54.67 | 381.04 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | establishment of protein localization to telomere (GO:0070200) | 0.002498 | 0.02503 | 555.17 | 3326.77 |
| 2 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.02503 | 555.17 | 3326.77 |
| 3 | lung morphogenesis (GO:0060425) | 0.002498 | 0.02503 | 555.17 | 3326.77 |
| 4 | positive regulation of toll-like receptor 9 signaling pathway (GO:0034165) | 0.002498 | 0.02503 | 555.17 | 3326.77 |
| 5 | negative regulation of regulatory T cell differentiation (GO:0045590) | 0.002498 | 0.02503 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.02566 | 555.17 | 3326.77 |
| 2 | RNA-directed DNA polymerase activity (GO:0003964) | 0.002997 | 0.02566 | 444.11 | 2580.41 |
| 3 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.02566 | 444.11 | 2580.41 |
| 4 | telomerase activity (GO:0003720) | 0.002997 | 0.02566 | 444.11 | 2580.41 |
| 5 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.02566 | 317.19 | 1751.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transferase complex, transferring phosphorus-containing groups (GO:0061695) | 0.004492 | 0.05839 | 277.53 | 1500.17 |
| 2 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.06320 | 184.98 | 932.06 |
| 3 | MHC protein complex (GO:0042611) | 0.009957 | 0.07753 | 116.79 | 538.34 |
| 4 | clathrin-coated endocytic vesicle (GO:0045334) | 0.0007857 | 0.03064 | 59.96 | 428.66 |
| 5 | lumenal side of endoplasmic reticulum membrane (GO:0098553) | 0.01392 | 0.07753 | 82.15 | 351.18 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| PTPN22 | – |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| NR5A1 | CORTICOTROPIN, OXYTOCIN |
| TERT | OMACETAXINE MEPESUCCINATE |
| BMP15 | – |
| NKX2-1 | – |
| BTNL2 | – |
| OBFC1 | ATENOLOL |
| FASLG | – |
