Centrilobular ground glass opacification on pulmonary HRCT (HP:0025180)
A hazy area of increased attenuation in centrilobular areas of the lung with preserved bronchial and vascular markings seen on a computer tomography scan. Centrilobular refers to a location that is central within secondary pulmonary lobules.
Synonyms: Centrilobular groundglass opacification, Centrilobular groundglass opacity
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | TGF-beta signaling pathway | 7.834e-18 | 8.618e-17 | 925.77 | 36464.13 |
| 2 | Cytokine-cytokine receptor interaction | 2.887e-16 | 1.588e-15 | 620.06 | 22186.23 |
| 3 | Hippo signaling pathway | 5.460e-11 | 2.002e-10 | 189.49 | 4477.76 |
| 4 | Fluid shear stress and atherosclerosis | 0.00003804 | 0.00009108 | 62.57 | 636.72 |
| 5 | Basal cell carcinoma | 0.0004323 | 0.0007926 | 81.68 | 632.69 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) | 1.850e-26 | 8.807e-24 | 199420.00 | 11816020.17 |
| 2 | BMP signaling pathway (GO:0030509) | 6.348e-26 | 1.511e-23 | 199350.00 | 11566105.39 |
| 3 | cellular response to BMP stimulus (GO:0071773) | 1.637e-25 | 2.598e-23 | 199290.00 | 11373779.66 |
| 4 | transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) | 1.197e-22 | 1.140e-20 | 198670.00 | 10028275.58 |
| 5 | positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) | 9.646e-24 | 1.148e-21 | 4725.47 | 250428.98 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | BMP receptor binding (GO:0070700) | 2.247e-11 | 2.772e-10 | 1480.07 | 36289.42 |
| 2 | transmembrane receptor protein serine/threonine kinase binding (GO:0070696) | 5.717e-11 | 5.288e-10 | 1109.89 | 26176.78 |
| 3 | cytokine activity (GO:0005125) | 3.764e-13 | 1.393e-11 | 278.65 | 7971.64 |
| 4 | transforming growth factor beta-activated receptor activity (GO:0005024) | 0.00001481 | 0.00009133 | 499.50 | 5554.53 |
| 5 | BMP binding (GO:0036122) | 0.00001481 | 0.00009133 | 499.50 | 5554.53 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | activin receptor complex (GO:0048179) | 0.003495 | 0.04214 | 370.07 | 2093.27 |
| 2 | spanning component of plasma membrane (GO:0044214) | 0.006482 | 0.04214 | 184.98 | 932.06 |
| 3 | spanning component of membrane (GO:0089717) | 0.009957 | 0.04315 | 116.79 | 538.34 |
| 4 | serine/threonine protein kinase complex (GO:1902554) | 0.01835 | 0.05964 | 61.59 | 246.23 |
| 5 | caveola (GO:0005901) | 0.02960 | 0.06771 | 37.53 | 132.12 |
Hub genes predicted as biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| BMPR2 | – |
| ACVR1 | – |
| SMAD6 | – |
| BMP4 | – |
| BMP2 | – |
| BMP10 | – |
| BMP7 | PEGASPARGASE |
| GDF5 | – |
| BMP6 | – |
| GDF2 | – |
