Polyneuropathy (HP:0001271)
A generalized disorder of peripheral nerves.
Synonyms: Peripheral nerve disease
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Peroxisome | 0.000007807 | 0.0001561 | 108.02 | 1270.32 |
| 2 | Ubiquinone and other terpenoid-quinone biosynthesis | 0.005488 | 0.03658 | 222.00 | 1155.57 |
| 3 | Spinocerebellar ataxia | 0.002200 | 0.02200 | 35.19 | 215.36 |
| 4 | Nucleotide excision repair | 0.02326 | 0.06795 | 48.17 | 181.19 |
| 5 | Cocaine addiction | 0.02424 | 0.06795 | 46.16 | 171.72 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | peroxisome organization (GO:0007031) | 2.058e-7 | 0.00001405 | 388.99 | 5988.96 |
| 2 | protein import into peroxisome matrix (GO:0016558) | 0.00001481 | 0.0004776 | 499.50 | 5554.53 |
| 3 | peroxisomal membrane transport (GO:0015919) | 2.616e-7 | 0.00001405 | 356.54 | 5403.81 |
| 4 | protein targeting to peroxisome (GO:0006625) | 3.266e-7 | 0.00001405 | 329.08 | 4914.57 |
| 5 | double-strand break repair via classical nonhomologous end joining (GO:0097680) | 0.002997 | 0.02974 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | opioid receptor binding (GO:0031628) | 0.002498 | 0.02156 | 555.17 | 3326.77 |
| 2 | peroxisome targeting sequence binding (GO:0000268) | 0.002997 | 0.02156 | 444.11 | 2580.41 |
| 3 | alpha-actinin binding (GO:0051393) | 0.00006174 | 0.001482 | 226.91 | 2199.35 |
| 4 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity (GO:0001640) | 0.004492 | 0.02156 | 277.53 | 1500.17 |
| 5 | G protein-coupled glutamate receptor activity (GO:0098988) | 0.004492 | 0.02156 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | integral component of peroxisomal membrane (GO:0005779) | 0.00001750 | 0.0001531 | 454.07 | 4973.59 |
| 2 | intrinsic component of peroxisomal membrane (GO:0031231) | 0.00002041 | 0.0001531 | 416.21 | 4494.85 |
| 3 | microbody membrane (GO:0031903) | 0.000001964 | 0.00003121 | 174.41 | 2291.88 |
| 4 | peroxisomal membrane (GO:0005778) | 0.000002081 | 0.00003121 | 170.91 | 2236.02 |
| 5 | G protein-coupled receptor dimeric complex (GO:0038037) | 0.003495 | 0.01498 | 370.07 | 2093.27 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PEX11B | – |
| PEX7 | – |
| PEX12 | – |
| SETX | – |
| GRM1 | MORPHINE, CAFFEINE |
| MYOT | – |
| COQ7 | – |
| PDYN | MORPHINE |
| ERCC6 | DEXTROMETHORPHAN, CYCLOSPORINE |
| LDB3 | – |
