Parkinsonism (HP:0001300)
Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.
Synonyms: Parkinsonian disease
Cross References: MSH:D020734, SNOMEDCT_US:32798002, UMLS:C0242422
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 0.0001737 | 0.006081 | 131.26 | 1136.48 |
| 2 | Proximal tubule bicarbonate reclamation | 0.01144 | 0.04634 | 100.85 | 450.83 |
| 3 | Taste transduction | 0.0008042 | 0.007873 | 59.24 | 422.16 |
| 4 | GABAergic synapse | 0.0008609 | 0.007873 | 57.19 | 403.64 |
| 5 | Morphine addiction | 0.0008998 | 0.007873 | 55.90 | 392.06 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.0002028 | 555.03 | 6273.06 |
| 2 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.0002028 | 555.03 | 6273.06 |
| 3 | membrane depolarization during action potential (GO:0086010) | 2.326e-7 | 0.00001337 | 372.06 | 5682.76 |
| 4 | membrane depolarization (GO:0051899) | 4.430e-7 | 0.00001698 | 294.99 | 4315.59 |
| 5 | anterograde dendritic transport (GO:0098937) | 0.002498 | 0.01306 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.0001049 | 624.44 | 7182.69 |
| 2 | voltage-gated sodium channel activity (GO:0005248) | 1.379e-7 | 0.000004689 | 450.47 | 7115.97 |
| 3 | extracellular ligand-gated ion channel activity (GO:0005230) | 0.00001235 | 0.0001049 | 555.03 | 6273.06 |
| 4 | GABA-gated chloride ion channel activity (GO:0022851) | 0.00001750 | 0.0001157 | 454.07 | 4973.59 |
| 5 | inhibitory extracellular ligand-gated ion channel activity (GO:0005237) | 0.00002041 | 0.0001157 | 416.21 | 4494.85 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.098e-8 | 0.000001341 | 611.51 | 10158.88 |
| 2 | sodium channel complex (GO:0034706) | 2.058e-7 | 0.000002264 | 388.99 | 5988.96 |
| 3 | GABA-A receptor complex (GO:1902711) | 0.00003830 | 0.0001685 | 293.72 | 2987.15 |
| 4 | neuron to neuron synapse (GO:0098984) | 0.003994 | 0.01098 | 317.19 | 1751.86 |
| 5 | dendrite membrane (GO:0032590) | 0.00009070 | 0.0003325 | 184.84 | 1720.52 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GABRG2 | – |
| SCN2A | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| SCN1A | ETHOSUXIMIDE |
| PCDH19 | – |
| ATP1A3 | ACETYLDIGITOXIN, DESLANOSIDE, DIGITOXIN |
| SCN1B | ZONISAMIDE |
| KIF5A | – |
| C9orf72 | – |
| ATXN2 | – |
