Paresthesia (HP:0003401)
Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause.
Synonyms: Pins and needles feeling, Tingling, Paresthesias
Cross References: MSH:D010292, SNOMEDCT_US:91019004, UMLS:C0030554
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Aldosterone-regulated sodium reabsorption | 6.931e-7 | 0.00008387 | 251.55 | 3567.44 |
| 2 | Endometrial cancer | 0.0003664 | 0.005434 | 88.99 | 704.07 |
| 3 | VEGF signaling pathway | 0.0003792 | 0.005434 | 87.43 | 688.70 |
| 4 | GnRH secretion | 0.0004462 | 0.005434 | 80.35 | 619.92 |
| 5 | Acute myeloid leukemia | 0.0004889 | 0.005434 | 76.63 | 584.21 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | chloride ion homeostasis (GO:0055064) | 0.00001010 | 0.0004991 | 624.44 | 7182.69 |
| 2 | monovalent inorganic anion homeostasis (GO:0055083) | 0.00001010 | 0.0004991 | 624.44 | 7182.69 |
| 3 | megakaryocyte differentiation (GO:0030219) | 0.00001481 | 0.0006097 | 499.50 | 5554.53 |
| 4 | regulation of glycoprotein metabolic process (GO:1903018) | 0.002498 | 0.02200 | 555.17 | 3326.77 |
| 5 | positive regulation of toll-like receptor 9 signaling pathway (GO:0034165) | 0.002498 | 0.02200 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | potassium:chloride symporter activity (GO:0015379) | 0.000008085 | 0.0002054 | 713.68 | 8368.26 |
| 2 | sodium:chloride symporter activity (GO:0015378) | 0.000008085 | 0.0002054 | 713.68 | 8368.26 |
| 3 | cation:chloride symporter activity (GO:0015377) | 0.00001010 | 0.0002054 | 624.44 | 7182.69 |
| 4 | anion:sodium symporter activity (GO:0015373) | 0.002498 | 0.02611 | 555.17 | 3326.77 |
| 5 | ATP-activated inward rectifier potassium channel activity (GO:0015272) | 0.002997 | 0.02611 | 444.11 | 2580.41 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.03479 | 555.17 | 3326.77 |
| 2 | intercalated disc (GO:0014704) | 0.01540 | 0.08724 | 73.93 | 308.54 |
| 3 | cell-cell contact zone (GO:0044291) | 0.02326 | 0.09237 | 48.17 | 181.19 |
| 4 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.09237 | 41.02 | 147.91 |
| 5 | voltage-gated potassium channel complex (GO:0008076) | 0.03591 | 0.09543 | 30.74 | 102.25 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| CLCNKB | – |
| KCNJ1 | GLYMIDINE, ACETOHEXAMIDE, MINOXIDIL, GLIMEPIRIDE, TOLBUTAMIDE, GLICLAZIDE, TOLAZAMIDE, GLIPIZIDE, CHLORPROPAMIDE |
| PIK3CA | – |
| KRAS | PANITUMUMAB, CETUXIMAB |
| SLC12A3 | POLYTHIAZIDE, BENDROFLUMETHIAZIDE, QUINETHAZONE, METOLAZONE, BENZTHIAZIDE, TRICHLORMETHIAZIDE, CHLOROTHIZIDE, CHLOROTHIAZIDE SODIUM, INDAPAMIDE, HYDROCHL OROTHIAZIDE |
| THPO | – |
| SLC12A1 | HYDROFLUMETHIAZIDE, METHYCLOTHIAZIDE, CHLORMERODRIN, FUROSEMIDE, TRICHLORMETHIAZIDE, BUMETANIDE, CHLORTHALIDONE, TORSEMIDE, METOLAZONE, BENDROFLUMETHIAZIDE |
| PTPN22 | – |
| GATA1 | CYTARABINE, DAUNORUBICIN |
