Paranoia (HP:0011999)
A persecutory delusion of supposed hostility of others.
Synonyms: Paranoia
Cross References: MSH:D010259, SNOMEDCT_US:191667009, UMLS:C1456784
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Porphyrin and chlorophyll metabolism | 0.0002010 | 0.0006029 | 121.64 | 1035.45 |
| 2 | Inositol phosphate metabolism | 0.03591 | 0.04747 | 30.74 | 102.25 |
| 3 | Phosphatidylinositol signaling system | 0.04747 | 0.04747 | 23.03 | 70.18 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | middle ear morphogenesis (GO:0042474) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 2 | protein retention in Golgi apparatus (GO:0045053) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 3 | lysosomal protein catabolic process (GO:1905146) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 4 | embryonic viscerocranium morphogenesis (GO:0048703) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 5 | enamel mineralization (GO:0070166) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | primary miRNA binding (GO:0070878) | 0.002997 | 0.02097 | 444.11 | 2580.41 |
| 2 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634) | 0.003495 | 0.02097 | 370.07 | 2093.27 |
| 3 | alkali metal ion binding (GO:0031420) | 0.006482 | 0.02917 | 184.98 | 932.06 |
| 4 | manganese ion binding (GO:0030145) | 0.02375 | 0.08549 | 47.15 | 176.34 |
| 5 | protein homodimerization activity (GO:0042803) | 0.0001825 | 0.003286 | 20.42 | 175.78 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuronal dense core vesicle (GO:0098992) | 0.002498 | 0.01124 | 555.17 | 3326.77 |
| 2 | mitochondrial envelope (GO:0005740) | 0.00002904 | 0.0005228 | 68.66 | 717.28 |
| 3 | mitochondrial intermembrane space (GO:0005758) | 0.0003664 | 0.002677 | 88.99 | 704.07 |
| 4 | organelle envelope lumen (GO:0031970) | 0.0004462 | 0.002677 | 80.35 | 619.92 |
| 5 | lipid droplet (GO:0005811) | 0.03785 | 0.1363 | 29.11 | 95.32 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ENSP00000331681 | – |
| DGCR2 | – |
| TBX1 | – |
| DGCR14 | – |
| CPOX | – |
| DGCR8 | – |
| HMBS | – |
| TIMM8A | – |
| VPS13A | – |
| IMPA1 | LITHIUM CARBONATE, LITHIUM CITRATE |
