Panic attack (HP:0025269)
A sudden episode of intense fear in a situation in which there is no danger or apparent cause.
Synonyms: Panic attack
Comment: The panic attack is accompanied by symptoms such as palpitations, sweating and chills or hot flushes. There may be a sensation of dyspnea (being out of breath), chest pain, or abdominal distress. Some individuals with panic attacks may experience depersonalization, a fear of going crazy, or a fear of dying.
Pubmed References: PMID:28613692
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Notch signaling pathway | 0.0003792 | 0.004117 | 87.43 | 688.70 |
| 2 | Long-term potentiation | 0.0004889 | 0.004117 | 76.63 | 584.21 |
| 3 | Renal cell carcinoma | 0.0005185 | 0.004117 | 74.34 | 562.35 |
| 4 | Adherens junction | 0.0005489 | 0.004117 | 72.18 | 541.87 |
| 5 | TGF-beta signaling pathway | 0.0009597 | 0.005265 | 54.07 | 375.73 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | peptidyl-lysine acetylation (GO:0018394) | 0.00001010 | 0.002869 | 624.44 | 7182.69 |
| 2 | N-terminal protein amino acid acetylation (GO:0006474) | 0.00002690 | 0.002885 | 356.71 | 3753.85 |
| 3 | positive regulation of transcription of Notch receptor target (GO:0007221) | 0.00003048 | 0.002885 | 332.92 | 3461.84 |
| 4 | glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860) | 0.002498 | 0.01650 | 555.17 | 3326.77 |
| 5 | Schwann cell differentiation (GO:0014037) | 0.002498 | 0.01650 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468) | 0.002498 | 0.01677 | 555.17 | 3326.77 |
| 2 | STAT family protein binding (GO:0097677) | 0.002997 | 0.01760 | 444.11 | 2580.41 |
| 3 | histone acetyltransferase activity (GO:0004402) | 0.0001038 | 0.002602 | 172.08 | 1578.44 |
| 4 | acetyltransferase activity (GO:0016407) | 0.0001107 | 0.002602 | 166.33 | 1515.06 |
| 5 | phosphatidylethanolamine binding (GO:0008429) | 0.004492 | 0.01796 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NURF complex (GO:0016589) | 0.002498 | 0.01915 | 555.17 | 3326.77 |
| 2 | ISWI-type complex (GO:0031010) | 0.004990 | 0.02869 | 246.68 | 1307.49 |
| 3 | MLL1 complex (GO:0071339) | 0.01293 | 0.03717 | 88.73 | 385.85 |
| 4 | MLL1/2 complex (GO:0044665) | 0.01293 | 0.03717 | 88.73 | 385.85 |
| 5 | axon (GO:0030424) | 0.0001190 | 0.002738 | 42.19 | 381.27 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MAX | – |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| SDHC | – |
| KIF1B | – |
| SDHAF2 | – |
| RET | CABOZANTINIB, VANDETANIB |
| EP300 | – |
| BPTF | – |
| CREBBP | – |
| TRIP12 | – |
