Pain (HP:0012531)
An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
Synonyms: Pain
Cross References: MSH:D010146, SNOMEDCT_US:22253000, UMLS:C0030193
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Pathways in cancer | 1.006e-11 | 1.479e-9 | 148.89 | 3770.13 |
| 2 | Thyroid cancer | 6.931e-7 | 0.000008491 | 251.55 | 3567.44 |
| 3 | Central carbon metabolism in cancer | 2.843e-8 | 8.638e-7 | 201.25 | 3496.91 |
| 4 | Colorectal cancer | 6.560e-8 | 0.000001607 | 161.85 | 2677.02 |
| 5 | Breast cancer | 4.901e-9 | 3.602e-7 | 139.77 | 2674.44 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of histone H3-K4 methylation (GO:0051571) | 0.00002354 | 0.0008257 | 384.17 | 4094.01 |
| 2 | response to muscle stretch (GO:0035994) | 0.00002354 | 0.0008257 | 384.17 | 4094.01 |
| 3 | regulation of phospholipase C activity (GO:1900274) | 0.00002354 | 0.0008257 | 384.17 | 4094.01 |
| 4 | sympathetic nervous system development (GO:0048485) | 0.00002690 | 0.0008402 | 356.71 | 3753.85 |
| 5 | regulation of neuroblast proliferation (GO:1902692) | 0.00003048 | 0.0008402 | 332.92 | 3461.84 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | I-SMAD binding (GO:0070411) | 0.00001750 | 0.0001966 | 454.07 | 4973.59 |
| 2 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.002498 | 0.01526 | 555.17 | 3326.77 |
| 3 | transcription coactivator binding (GO:0001223) | 0.00004255 | 0.0003900 | 277.39 | 2791.90 |
| 4 | G protein-coupled serotonin receptor binding (GO:0031821) | 0.002997 | 0.01602 | 444.11 | 2580.41 |
| 5 | transcription coregulator binding (GO:0001221) | 0.000002081 | 0.00005563 | 170.91 | 2236.02 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.03747 | 555.17 | 3326.77 |
| 2 | beta-catenin-TCF complex (GO:1990907) | 0.006482 | 0.04862 | 184.98 | 932.06 |
| 3 | intercalated disc (GO:0014704) | 0.01540 | 0.05461 | 73.93 | 308.54 |
| 4 | catenin complex (GO:0016342) | 0.01540 | 0.05461 | 73.93 | 308.54 |
| 5 | heterotrimeric G-protein complex (GO:0005834) | 0.01638 | 0.05461 | 69.30 | 284.93 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KRAS | PANITUMUMAB, CETUXIMAB |
| CTNNB1 | FLUORESCEN SODIUM |
| ESR1 | CLOMIPHENE, LEVONORGESTREL |
| PIK3CA | – |
| SMAD4 | LYSINE, ALECTINIB |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| KIT | NILOTINIB, IMATINIB |
| RET | CABOZANTINIB, VANDETANIB |
| ERBB4 | DACOMITINIB |
| GNAQ | VERTEPORFIN |
