Orthostatic hypotension (HP:0001278)
A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position.
Synonyms: Decrease in blood pressure upon standing up, Postural hypotension
Cross References: MSH:D007024, SNOMEDCT_US:28651003, UMLS:C0020651
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | JAK-STAT signaling pathway | 0.002812 | 0.04780 | 30.98 | 182.00 |
| 2 | Sphingolipid metabolism | 0.02424 | 0.09613 | 46.16 | 171.72 |
| 3 | Inflammatory bowel disease | 0.03204 | 0.09613 | 34.59 | 119.03 |
| 4 | Adipocytokine signaling pathway | 0.03398 | 0.09613 | 32.55 | 110.09 |
| 5 | Cytokine-cytokine receptor interaction | 0.009024 | 0.06752 | 16.81 | 79.12 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | negative regulation of response to food (GO:0032096) | 0.002498 | 0.03060 | 555.17 | 3326.77 |
| 2 | activation of protein kinase C activity (GO:1990051) | 0.002498 | 0.03060 | 555.17 | 3326.77 |
| 3 | positive regulation of cell fate commitment (GO:0010455) | 0.002498 | 0.03060 | 555.17 | 3326.77 |
| 4 | anion homeostasis (GO:0055081) | 0.002498 | 0.03060 | 555.17 | 3326.77 |
| 5 | response to acetylcholine (GO:1905144) | 0.002498 | 0.03060 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | interleukin-12 receptor binding (GO:0005143) | 0.002997 | 0.03163 | 444.11 | 2580.41 |
| 2 | acetylcholine-gated cation-selective channel activity (GO:0022848) | 0.005488 | 0.03163 | 222.00 | 1155.57 |
| 3 | arylsulfatase activity (GO:0004065) | 0.006979 | 0.03163 | 170.74 | 847.70 |
| 4 | peptide hormone receptor binding (GO:0051428) | 0.006979 | 0.03163 | 170.74 | 847.70 |
| 5 | sulfuric ester hydrolase activity (GO:0008484) | 0.008469 | 0.03163 | 138.71 | 661.82 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | chromaffin granule (GO:0042583) | 0.002498 | 0.02997 | 555.17 | 3326.77 |
| 2 | acetylcholine-gated channel complex (GO:0005892) | 0.006979 | 0.05360 | 170.74 | 847.70 |
| 3 | ion channel complex (GO:0034702) | 0.01737 | 0.08931 | 65.22 | 264.33 |
| 4 | dendrite (GO:0030425) | 0.0002722 | 0.009798 | 31.66 | 259.88 |
| 5 | mitochondrial intermembrane space (GO:0005758) | 0.02863 | 0.1048 | 38.86 | 138.07 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GIGYF2 | – |
| CHCHD2 | – |
| SPG11 | – |
| IL12RB1 | – |
| LEP | SOYBEAN OIL, GEMFIBROZIL |
| CYB561 | – |
| AAAS | – |
| IKBKAP | – |
| ARSA | DECAMETHONIUM |
| CHRNA3 | VARENICLINE, PENTOLINIUM TARTRATE, TREMETHAPHAN CAMYSLATE, MECAMYLAMINE HYDROCHLORIDE |
