Ocular pain (HP:0200026)
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.
Synonyms: Eye pain
Cross References: MSH:D058447, SNOMEDCT_US:41652007, UMLS:C0151827
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Long-term depression | 0.0003921 | 0.005647 | 85.91 | 673.90 |
| 2 | GnRH secretion | 0.0004462 | 0.005647 | 80.35 | 619.92 |
| 3 | Cortisol synthesis and secretion | 0.0004602 | 0.005647 | 79.08 | 607.60 |
| 4 | Insulin secretion | 0.0008042 | 0.005647 | 59.24 | 422.16 |
| 5 | Gap junction | 0.0008418 | 0.005647 | 57.86 | 409.65 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phototransduction, visible light (GO:0007603) | 0.00002354 | 0.0006787 | 384.17 | 4094.01 |
| 2 | detection of visible light (GO:0009584) | 0.00003048 | 0.0006787 | 332.92 | 3461.84 |
| 3 | negative regulation of keratinocyte differentiation (GO:0045617) | 0.002498 | 0.02248 | 555.17 | 3326.77 |
| 4 | protein side chain deglutamylation (GO:0035610) | 0.002498 | 0.02248 | 555.17 | 3326.77 |
| 5 | C-terminal protein deglutamylation (GO:0035609) | 0.002498 | 0.02248 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | G protein-coupled serotonin receptor binding (GO:0031821) | 0.000003371 | 0.00008765 | 1249.13 | 15739.23 |
| 2 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.02138 | 555.17 | 3326.77 |
| 3 | N-acetylglucosamine 6-O-sulfotransferase activity (GO:0001517) | 0.003495 | 0.02138 | 370.07 | 2093.27 |
| 4 | voltage-gated sodium channel activity (GO:0005248) | 0.01095 | 0.03558 | 105.66 | 476.99 |
| 5 | metallocarboxypeptidase activity (GO:0004181) | 0.01441 | 0.04163 | 79.21 | 335.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | hemidesmosome (GO:0030056) | 0.003495 | 0.02964 | 370.07 | 2093.27 |
| 2 | heterotrimeric G-protein complex (GO:0005834) | 0.0001178 | 0.002474 | 160.96 | 1456.09 |
| 3 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.02964 | 138.71 | 661.82 |
| 4 | sodium channel complex (GO:0034706) | 0.01243 | 0.03264 | 92.44 | 405.55 |
| 5 | basement membrane (GO:0005604) | 0.02570 | 0.04907 | 43.44 | 159.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| COL8A2 | – |
| GNA11 | BINIMETINIB, CABOZANTINIB |
| GRHL2 | – |
| VSX1 | – |
| GNAQ | VERTEPORFIN |
| OVOL2 | – |
| CHST6 | – |
| AGBL1 | – |
| SCN9A | – |
| COL17A1 | – |
