Myalgia (HP:0003326)
Pain in muscle.
Synonyms: Muscle ache, Muscle pain, Myalgias
Cross References: MSH:D063806, SNOMEDCT_US:68962001, UMLS:C0231528
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Mannose type O-glycan biosynthesis | 0.00005661 | 0.0003396 | 237.73 | 2324.81 |
| 2 | Glucagon signaling pathway | 0.00001738 | 0.0003129 | 81.95 | 898.15 |
| 3 | Insulin signaling pathway | 0.00003643 | 0.0003278 | 63.51 | 649.04 |
| 4 | Starch and sucrose metabolism | 0.01786 | 0.06429 | 63.35 | 255.00 |
| 5 | Viral myocarditis | 0.02960 | 0.08458 | 37.53 | 132.12 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular glucan metabolic process (GO:0006073) | 1.482e-8 | 0.000001771 | 1070.46 | 19297.66 |
| 2 | regulation of skeletal muscle contraction (GO:0014819) | 0.000004719 | 0.0001410 | 999.25 | 12254.80 |
| 3 | glucan catabolic process (GO:0009251) | 4.082e-8 | 0.000002401 | 713.50 | 12139.53 |
| 4 | glycogen catabolic process (GO:0005980) | 4.082e-8 | 0.000002401 | 713.50 | 12139.53 |
| 5 | cellular polysaccharide catabolic process (GO:0044247) | 5.023e-8 | 0.000002401 | 658.58 | 11068.58 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | 1,4-alpha-oligoglucan phosphorylase activity (GO:0004645) | 0.002498 | 0.02089 | 555.17 | 3326.77 |
| 2 | sodium ion binding (GO:0031402) | 0.002997 | 0.02089 | 444.11 | 2580.41 |
| 3 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.02089 | 370.07 | 2093.27 |
| 4 | potassium channel inhibitor activity (GO:0019870) | 0.004492 | 0.02089 | 277.53 | 1500.17 |
| 5 | Tat protein binding (GO:0030957) | 0.004990 | 0.02089 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | filopodium membrane (GO:0031527) | 0.005985 | 0.05387 | 201.81 | 1032.95 |
| 2 | sarcolemma (GO:0042383) | 0.0002944 | 0.007949 | 99.70 | 810.62 |
| 3 | myofibril (GO:0030016) | 0.01342 | 0.06661 | 85.32 | 367.79 |
| 4 | rough endoplasmic reticulum (GO:0005791) | 0.01441 | 0.06661 | 79.21 | 335.86 |
| 5 | neuromuscular junction (GO:0031594) | 0.01884 | 0.06661 | 59.92 | 237.98 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CAV3 | – |
| MYOT | – |
| FKTN | – |
| FKRP | – |
| CAPN3 | – |
| DMD | ETEPLIRSEN, ATALUREN |
| TRIM32 | |
| PYGM | – |
| PHKA1 | – |
| PHKB | – |
