Muscle spasm (HP:0003394)
Sudden and involuntary contractions of one or more muscles.
Synonyms: Muscle cramps
Cross References: MSH:D009120, SNOMEDCT_US:55300003, UMLS:C0026821
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Amyotrophic lateral sclerosis | 6.887e-9 | 6.199e-8 | 82.26 | 1545.90 |
| 2 | mRNA surveillance pathway | 0.001042 | 0.003127 | 51.81 | 355.72 |
| 3 | Pathways of neurodegeneration | 0.00005889 | 0.0002650 | 27.63 | 269.09 |
| 4 | Basal transcription factors | 0.02228 | 0.03342 | 50.37 | 191.61 |
| 5 | RNA transport | 0.003686 | 0.007059 | 26.91 | 150.79 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of cytoplasmic mRNA processing body assembly (GO:0010603) | 0.003495 | 0.03848 | 370.07 | 2093.27 |
| 2 | intermediate filament bundle assembly (GO:0045110) | 0.003495 | 0.03848 | 370.07 | 2093.27 |
| 3 | regulation of translational termination (GO:0006449) | 0.003994 | 0.03848 | 317.19 | 1751.86 |
| 4 | negative regulation of mRNA catabolic process (GO:1902373) | 0.00009070 | 0.005179 | 184.84 | 1720.52 |
| 5 | RNA stabilization (GO:0043489) | 0.0001178 | 0.005179 | 160.96 | 1456.09 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | epidermal growth factor receptor binding (GO:0005154) | 0.01293 | 0.04721 | 88.73 | 385.85 |
| 2 | kinesin binding (GO:0019894) | 0.01441 | 0.04721 | 79.21 | 335.86 |
| 3 | miRNA binding (GO:0035198) | 0.01490 | 0.04721 | 76.48 | 321.69 |
| 4 | regulatory RNA binding (GO:0061980) | 0.01983 | 0.04721 | 56.84 | 222.86 |
| 5 | cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) | 0.02179 | 0.04721 | 51.54 | 197.22 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurofibrillary tangle (GO:0097418) | 0.002498 | 0.03372 | 555.17 | 3326.77 |
| 2 | nuclear inner membrane (GO:0005637) | 0.01392 | 0.08047 | 82.15 | 351.18 |
| 3 | cyclin-dependent protein kinase holoenzyme complex (GO:0000307) | 0.01490 | 0.08047 | 76.48 | 321.69 |
| 4 | serine/threonine protein kinase complex (GO:1902554) | 0.01835 | 0.08258 | 61.59 | 246.23 |
| 5 | SCF ubiquitin ligase complex (GO:0019005) | 0.02863 | 0.09043 | 38.86 | 138.07 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| C9orf72 | – |
| FUS | TRETINOIN |
| ATXN2 | – |
| MATR3 | – |
| NEK1 | – |
| FIG4 | – |
| NEFH | – |
| TAF15 | – |
| CCNF | – |
| GLE1 | – |
