Memory impairment (HP:0002354)
An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.
Synonyms: Forgetfulness, Memory impairment, Memory loss, Memory problems, Poor memory
Comment: Affected individuals tend to lose their train of thought in conversation, begin tasks but forget their intention while doing it, repeat things often during conversations, and have difficulties in tasks of daily living.
Cross References: MSH:D008569, SNOMEDCT_US:386807006, SNOMEDCT_US:55533009, UMLS:C0233794, UMLS:C0542476, UMLS:C0751295
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Aldosterone-regulated sodium reabsorption | 6.931e-7 | 0.00001326 | 251.55 | 3567.44 |
| 2 | VEGF signaling pathway | 0.000002883 | 0.00003960 | 152.56 | 1946.09 |
| 3 | Cholinergic synapse | 1.976e-7 | 0.000007963 | 121.60 | 1877.08 |
| 4 | Growth hormone synthesis, secretion and action | 2.434e-7 | 0.000007963 | 115.22 | 1754.62 |
| 5 | GnRH secretion | 0.000003690 | 0.00004313 | 140.02 | 1751.57 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular response to heat (GO:0034605) | 6.371e-7 | 0.0002427 | 259.18 | 3697.58 |
| 2 | activation of protein kinase A activity (GO:0034199) | 0.00003048 | 0.004313 | 332.92 | 3461.84 |
| 3 | negative regulation of tubulin deacetylation (GO:1904428) | 0.002498 | 0.02410 | 555.17 | 3326.77 |
| 4 | positive regulation of protein localization to synapse (GO:1902474) | 0.002498 | 0.02410 | 555.17 | 3326.77 |
| 5 | response to morphine (GO:0043278) | 0.002498 | 0.02410 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cAMP-dependent protein kinase activity (GO:0004691) | 0.002498 | 0.02136 | 555.17 | 3326.77 |
| 2 | cyclic nucleotide-dependent protein kinase activity (GO:0004690) | 0.002997 | 0.02136 | 444.11 | 2580.41 |
| 3 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.003495 | 0.02136 | 370.07 | 2093.27 |
| 4 | minor groove of adenine-thymine-rich DNA binding (GO:0003680) | 0.003495 | 0.02136 | 370.07 | 2093.27 |
| 5 | protein serine/threonine/tyrosine kinase activity (GO:0004712) | 0.00008446 | 0.005068 | 191.96 | 1800.45 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | nuclear inclusion body (GO:0042405) | 0.00001235 | 0.0004197 | 555.03 | 6273.06 |
| 2 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.01213 | 555.17 | 3326.77 |
| 3 | neurofibrillary tangle (GO:0097418) | 0.002498 | 0.01213 | 555.17 | 3326.77 |
| 4 | glial cell projection (GO:0097386) | 0.006979 | 0.02637 | 170.74 | 847.70 |
| 5 | membrane raft (GO:0045121) | 0.00006115 | 0.001040 | 53.12 | 515.34 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MAPT | – |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| KRAS | PANITUMUMAB, CETUXIMAB |
| ATXN3 | – |
| PIK3CA | – |
| PRKACA | – |
| ATXN1 | – |
| C9orf72 | – |
| PRKAR1A | – |
| PRKCG | – |
