Mania (HP:0100754)
A state of abnormally elevated or irritable mood, arousal, and or energy levels.
Synonyms: Manic
Pubmed References: PMID:15104084
Cross References: MSH:D001714, SNOMEDCT_US:231494001, UMLS:C0338831
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Long-term potentiation | 0.0004889 | 0.02224 | 76.63 | 584.21 |
| 2 | Morphine addiction | 0.0008998 | 0.02224 | 55.90 | 392.06 |
| 3 | Progesterone-mediated oocyte maturation | 0.001085 | 0.02224 | 50.74 | 346.39 |
| 4 | Platelet activation | 0.001661 | 0.02224 | 40.71 | 260.58 |
| 5 | Tyrosine metabolism | 0.01786 | 0.08975 | 63.35 | 255.00 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | activation of protein kinase A activity (GO:0034199) | 0.00003048 | 0.002871 | 332.92 | 3461.84 |
| 2 | negative regulation of cGMP-mediated signaling (GO:0010754) | 0.002498 | 0.02483 | 555.17 | 3326.77 |
| 3 | coronary artery morphogenesis (GO:0060982) | 0.002498 | 0.02483 | 555.17 | 3326.77 |
| 4 | middle ear morphogenesis (GO:0042474) | 0.002498 | 0.02483 | 555.17 | 3326.77 |
| 5 | embryonic viscerocranium morphogenesis (GO:0048703) | 0.002498 | 0.02483 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cAMP-dependent protein kinase activity (GO:0004691) | 0.002498 | 0.02517 | 555.17 | 3326.77 |
| 2 | cyclic nucleotide-dependent protein kinase activity (GO:0004690) | 0.002997 | 0.02517 | 444.11 | 2580.41 |
| 3 | ribosomal protein S6 kinase activity (GO:0004711) | 0.003495 | 0.02517 | 370.07 | 2093.27 |
| 4 | cAMP-dependent protein kinase inhibitor activity (GO:0004862) | 0.003994 | 0.02517 | 317.19 | 1751.86 |
| 5 | L-aspartate transmembrane transporter activity (GO:0015183) | 0.004492 | 0.02517 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | plasma membrane raft (GO:0044853) | 0.0007315 | 0.01390 | 62.22 | 449.25 |
| 2 | calcium channel complex (GO:0034704) | 0.02228 | 0.1128 | 50.37 | 191.61 |
| 3 | membrane raft (GO:0045121) | 0.002846 | 0.02704 | 30.79 | 180.49 |
| 4 | acrosomal vesicle (GO:0001669) | 0.02375 | 0.1128 | 47.15 | 176.34 |
| 5 | cation channel complex (GO:0034703) | 0.03591 | 0.1365 | 30.74 | 102.25 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PRKACA | – |
| TBX1 | – |
| PRKAR1A | – |
| PDE11A | TADALAFIL |
| C10orf2 | – |
| GP1BB | – |
| POLG2 | – |
| COMT | ENTACAPONE, OPICAPONE, REMIFENTANIL, SUFENTANIL, MODAFINIL, MORPHINE, METHADONE |
| RPS6KA3 | – |
| SLC25A13 | – |
