Keratoconjunctivitis sicca (HP:0001097)
Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids.
Synonyms: Dry eye syndrome, Dry eyes, Keratitis sicca, Xerophthalmia
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nucleotide excision repair | 0.000001443 | 0.00004472 | 194.28 | 2612.86 |
| 2 | Basal transcription factors | 0.0002202 | 0.003413 | 115.97 | 976.58 |
| 3 | Asthma | 0.01540 | 0.08063 | 73.93 | 308.54 |
| 4 | Allograft rejection | 0.01884 | 0.08063 | 59.92 | 237.98 |
| 5 | Graft-versus-host disease | 0.02081 | 0.08063 | 54.06 | 209.35 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.01599 | 555.17 | 3326.77 |
| 2 | nucleotide-excision repair, DNA incision, 3′-to lesion (GO:0006295) | 0.00004701 | 0.001831 | 262.78 | 2618.60 |
| 3 | nucleotide-excision repair, preincision complex stabilization (GO:0006293) | 0.00004701 | 0.001831 | 262.78 | 2618.60 |
| 4 | regulation of T-helper cell differentiation (GO:0045622) | 0.002997 | 0.01599 | 444.11 | 2580.41 |
| 5 | positive regulation of T cell mediated immune response to tumor cell (GO:0002842) | 0.002997 | 0.01599 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | gap junction channel activity involved in cell communication by electrical coupling (GO:1903763) | 0.002997 | 0.02797 | 444.11 | 2580.41 |
| 2 | 5′-3′ DNA helicase activity (GO:0043139) | 0.003495 | 0.02797 | 370.07 | 2093.27 |
| 3 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.02797 | 317.19 | 1751.86 |
| 4 | MHC class II receptor activity (GO:0032395) | 0.004990 | 0.02797 | 246.68 | 1307.49 |
| 5 | MHC class II protein complex binding (GO:0023026) | 0.008469 | 0.02797 | 138.71 | 661.82 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transcription factor TFIIH core complex (GO:0000439) | 0.00001010 | 0.0003925 | 624.44 | 7182.69 |
| 2 | transcription factor TFIIH holo complex (GO:0005675) | 0.00001481 | 0.0003925 | 499.50 | 5554.53 |
| 3 | hemidesmosome (GO:0030056) | 0.003495 | 0.04631 | 370.07 | 2093.27 |
| 4 | transcription factor TFIID complex (GO:0005669) | 0.0001038 | 0.001834 | 172.08 | 1578.44 |
| 5 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.05268 | 184.98 | 932.06 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ERCC6 | DEXTROMETHORPHAN, CYCLOSPORINE |
| GTF2H5 | – |
| ERCC2 | OXALIPLATIN, LEUCOVORIN |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| BTNL2 | – |
| COL17A1 | – |
| MEFV | – |
| RNF125 | – |
| GJB6 | CARBENOXOLONE |
| SCN9A | – |
