Insomnia (HP:0100785)
Persistent difficulty initiating or maintaining sleep.
Synonyms: Fragmented sleep, Difficulty staying or falling asleep
Pubmed References: PMID:23423416
Cross References: MSH:D007319, SNOMEDCT_US:193462001, UMLS:C0917801
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Bile secretion | 0.00001034 | 0.00008268 | 98.04 | 1125.55 |
| 2 | ABC transporters | 0.0002202 | 0.0008809 | 115.97 | 976.58 |
| 3 | Arginine biosynthesis | 0.01095 | 0.02684 | 105.66 | 476.99 |
| 4 | Collecting duct acid secretion | 0.01342 | 0.02684 | 85.32 | 367.79 |
| 5 | Porphyrin and chlorophyll metabolism | 0.02130 | 0.03297 | 52.77 | 203.13 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of bile acid metabolic process (GO:1904251) | 0.000004719 | 0.0001850 | 999.25 | 12254.80 |
| 2 | bile acid and bile salt transport (GO:0015721) | 2.929e-7 | 0.00002871 | 342.26 | 5148.70 |
| 3 | monocarboxylic acid transport (GO:0015718) | 1.229e-8 | 0.000002408 | 250.78 | 4567.88 |
| 4 | negative regulation of cellular respiration (GO:1901856) | 0.002498 | 0.02331 | 555.17 | 3326.77 |
| 5 | regulation of microvillus assembly (GO:0032534) | 0.002498 | 0.02331 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glycerophospholipid flippase activity (GO:0140333) | 0.00001481 | 0.0006813 | 499.50 | 5554.53 |
| 2 | phosphatidylcholine flippase activity (GO:0140345) | 0.002498 | 0.01435 | 555.17 | 3326.77 |
| 3 | phosphatidylcholine floppase activity (GO:0090554) | 0.002498 | 0.01435 | 555.17 | 3326.77 |
| 4 | anion:sodium symporter activity (GO:0015373) | 0.002498 | 0.01435 | 555.17 | 3326.77 |
| 5 | phosphatidylserine flippase activity (GO:0140346) | 0.002498 | 0.01435 | 555.17 | 3326.77 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial intermembrane space (GO:0005758) | 0.02863 | 0.1577 | 38.86 | 138.07 |
| 2 | recycling endosome membrane (GO:0055038) | 0.02863 | 0.1577 | 38.86 | 138.07 |
| 3 | organelle envelope lumen (GO:0031970) | 0.03155 | 0.1577 | 35.14 | 121.47 |
| 4 | integral component of plasma membrane (GO:0005887) | 0.0003728 | 0.007457 | 12.80 | 101.01 |
| 5 | mitochondrial envelope (GO:0005740) | 0.06173 | 0.2086 | 17.52 | 48.78 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NR1H4 | OBETICHOLIC ACID, CHENODIOL |
| ATP8B1 | – |
| ABCB4 | BENZQUINAMIDE |
| ABCB11 | CHOLIC ACID, CHENODIOL, HYDROXYPROGESTERONE CAPROATE |
| NAGS | – |
| CPOX | – |
| CLCNKB | – |
| MLXIPL | – |
| SLC25A13 | – |
| SLC12A3 | POLYTHIAZIDE, BENDROFLUMETHIAZIDE, QUINETHAZONE, METOLAZONE, BENZTHIAZIDE, TRICHLORMETHIAZIDE, CHLOROTHIZIDE, CHLOROTHIAZIDE SODIUM, INDAPAMIDE, HYDROCHL OROTHIAZIDE |
