Increased circulating ferritin concentration (HP:0003281)
Increased concentration of ferritin in the blood circulation.
Synonyms: Elevated serum ferritin, High ferritin level, Increased ferritin, Increased serum ferritin level, Hyperferritinaemia, Hyperferritinemia, Increased plasma ferritin
Comment: Ferritin is a ubiquitous intracellular protein that stores iron. Ferritin levels measured in serum usually have a direct correlation with the total amount of iron stored in the body, but ferritin levels may also be increased with anemia of chronic disease or in the course of an acute phase reaction.
Cross References: UMLS:C0241013, UMLS:C0743912, UMLS:C3854388
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Vitamin digestion and absorption | 0.01194 | 0.07105 | 96.46 | 427.12 |
| 2 | Allograft rejection | 0.01884 | 0.07105 | 59.92 | 237.98 |
| 3 | Apoptosis | 0.002170 | 0.04193 | 35.45 | 217.39 |
| 4 | Graft-versus-host disease | 0.02081 | 0.07105 | 54.06 | 209.35 |
| 5 | Type I diabetes mellitus | 0.02130 | 0.07105 | 52.77 | 203.13 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of nucleotide-binding oligomerization domain containing signaling pathway (GO:0070424) | 0.002498 | 0.02906 | 555.17 | 3326.77 |
| 2 | folate transmembrane transport (GO:0098838) | 0.002498 | 0.02906 | 555.17 | 3326.77 |
| 3 | drug transport (GO:0015893) | 0.002498 | 0.02906 | 555.17 | 3326.77 |
| 4 | cyclic-GMP-AMP transmembrane import across plasma membrane (GO:0140361) | 0.002498 | 0.02906 | 555.17 | 3326.77 |
| 5 | guanine nucleotide transmembrane transport (GO:1903790) | 0.002997 | 0.02906 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | folic acid transmembrane transporter activity (GO:0008517) | 0.002498 | 0.02463 | 555.17 | 3326.77 |
| 2 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634) | 0.003495 | 0.02463 | 370.07 | 2093.27 |
| 3 | glycine transmembrane transporter activity (GO:0015187) | 0.003994 | 0.02463 | 317.19 | 1751.86 |
| 4 | endopeptidase activator activity (GO:0061133) | 0.004990 | 0.02463 | 246.68 | 1307.49 |
| 5 | purine ribonucleotide transmembrane transporter activity (GO:0005346) | 0.005488 | 0.02463 | 222.00 | 1155.57 |
GO: Celullar Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cytolytic granule (GO:0044194) | 0.000004719 | 0.00008965 | 999.25 | 12254.80 |
| 2 | primary lysosome (GO:0005766) | 0.005488 | 0.05213 | 222.00 | 1155.57 |
| 3 | mitochondrial intermembrane space (GO:0005758) | 0.02863 | 0.09991 | 38.86 | 138.07 |
| 4 | spindle microtubule (GO:0005876) | 0.03009 | 0.09991 | 36.91 | 129.31 |
| 5 | organelle envelope lumen (GO:0031970) | 0.03155 | 0.09991 | 35.14 | 121.47 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| XIAP | ETOPOSIDE PHOSPHATE |
| SLC25A38 | – |
| STXBP2 | EMAPALUMAB |
| PRF1 | EMAPALUMAB |
| GLRX5 | – |
| CPOX | – |
| NLRC4 | – |
| SLC19A1 | RALTITREXED, PEMETREXED, LEUCOVORIN |
| TTC26 | – |
| SLC7A7 | – |
