Impulsivity (HP:0100710)
Acting on the spur of the moment in response to immediate stimuli; acting on a momentary basis without a plan or consideration of outcomes; difficulty establishing or following plans; a sense of urgency and self-harming behavior under emotional distress.
Synonyms: Impulsive, Impulsivity
Pubmed References: PMID:23902698
Cross References: MSH:D007175, UMLS:C0021125
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 2.854e-9 | 8.848e-8 | 369.52 | 7270.07 |
| 2 | GABAergic synapse | 0.000009993 | 0.0001104 | 99.19 | 1142.03 |
| 3 | Morphine addiction | 0.00001068 | 0.0001104 | 96.93 | 1109.48 |
| 4 | Dopaminergic synapse | 0.00003260 | 0.0002526 | 65.98 | 681.69 |
| 5 | Retrograde endocannabinoid signaling | 0.00004587 | 0.0002844 | 58.66 | 585.95 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization (GO:0051899) | 1.893e-12 | 1.703e-10 | 739.37 | 19957.87 |
| 2 | neuronal action potential (GO:0019228) | 2.294e-10 | 1.032e-8 | 739.70 | 16417.99 |
| 3 | membrane depolarization during action potential (GO:0086010) | 4.685e-10 | 1.405e-8 | 605.09 | 12998.28 |
| 4 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.00008547 | 555.03 | 6273.06 |
| 5 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.00008547 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 2.294e-10 | 8.719e-9 | 739.70 | 16417.99 |
| 2 | sodium channel activity (GO:0005272) | 2.307e-9 | 4.382e-8 | 391.29 | 7781.87 |
| 3 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.00009840 | 624.44 | 7182.69 |
| 4 | extracellular ligand-gated ion channel activity (GO:0005230) | 0.00001235 | 0.00009840 | 555.03 | 6273.06 |
| 5 | GABA-gated chloride ion channel activity (GO:0022851) | 0.00001750 | 0.0001108 | 454.07 | 4973.59 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 7.474e-11 | 1.570e-9 | 1024.46 | 23887.38 |
| 2 | sodium channel complex (GO:0034706) | 3.965e-10 | 3.627e-9 | 633.94 | 13723.68 |
| 3 | GABA-A receptor complex (GO:1902711) | 0.00003830 | 0.0001341 | 293.72 | 2987.15 |
| 4 | integral component of plasma membrane (GO:0005887) | 5.182e-10 | 3.627e-9 | 115.51 | 2469.57 |
| 5 | NMDA selective glutamate receptor complex (GO:0017146) | 0.003994 | 0.008387 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN1A | ETHOSUXIMIDE |
| SCN2A | – |
| KCNA2 | – |
| GABRG2 | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| SCN8A | – |
| PCDH19 | – |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| SCN1B | ZONISAMIDE |
| CACNA1B | ZICONOTIDE, ZICONOTIDE ACETATE, AMLODIPINE, LEVETIRACETAM |
