Hypofibrinogenemia (HP:0011900)
Decreased concentration of fibrinogen in the blood.
Synonyms: Low fibrinogen activity, Low fibrinogen level
Cross References: SNOMEDCT_US:234457009, UMLS:C0553681
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Apoptosis | 0.00004054 | 0.001541 | 61.21 | 618.98 |
| 2 | Allograft rejection | 0.01884 | 0.08352 | 59.92 | 237.98 |
| 3 | Graft-versus-host disease | 0.02081 | 0.08352 | 54.06 | 209.35 |
| 4 | Type I diabetes mellitus | 0.02130 | 0.08352 | 52.77 | 203.13 |
| 5 | Necroptosis | 0.002710 | 0.04426 | 31.58 | 186.67 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of nucleotide-binding oligomerization domain containing signaling pathway (GO:0070424) | 0.002498 | 0.03427 | 555.17 | 3326.77 |
| 2 | positive regulation of killing of cells of other organism (GO:0051712) | 0.002997 | 0.03427 | 444.11 | 2580.41 |
| 3 | taurine metabolic process (GO:0019530) | 0.002997 | 0.03427 | 444.11 | 2580.41 |
| 4 | negative regulation of cAMP-dependent protein kinase activity (GO:2000480) | 0.003994 | 0.03427 | 317.19 | 1751.86 |
| 5 | regulation of pattern recognition receptor signaling pathway (GO:0062207) | 0.003994 | 0.03427 | 317.19 | 1751.86 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cAMP-dependent protein kinase inhibitor activity (GO:0004862) | 0.003994 | 0.03467 | 317.19 | 1751.86 |
| 2 | glucocorticoid receptor binding (GO:0035259) | 0.004492 | 0.03467 | 277.53 | 1500.17 |
| 3 | protein-glutamine gamma-glutamyltransferase activity (GO:0003810) | 0.004492 | 0.03467 | 277.53 | 1500.17 |
| 4 | cAMP-dependent protein kinase regulator activity (GO:0008603) | 0.004990 | 0.03467 | 246.68 | 1307.49 |
| 5 | endopeptidase activator activity (GO:0061133) | 0.004990 | 0.03467 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cytolytic granule (GO:0044194) | 0.000004719 | 0.00006604 | 999.25 | 12254.80 |
| 2 | spectrin-associated cytoskeleton (GO:0014731) | 0.000006290 | 0.00006604 | 832.67 | 9972.50 |
| 3 | intrinsic component of the cytoplasmic side of the plasma membrane (GO:0031235) | 0.003994 | 0.01677 | 317.19 | 1751.86 |
| 4 | primary lysosome (GO:0005766) | 0.005488 | 0.01921 | 222.00 | 1155.57 |
| 5 | cytoplasmic side of plasma membrane (GO:0009898) | 0.0003294 | 0.002306 | 94.04 | 754.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| XIAP | ETOPOSIDE PHOSPHATE |
| PRF1 | EMAPALUMAB |
| EPB42 | – |
| ANK1 | – |
| STXBP2 | EMAPALUMAB |
| SPTA1 | – |
| STAT5B | TOFACITINIB, DASATINIB, EPOETIN ALFA |
| AHCY | – |
| NLRC4 | – |
| PRKAR1A | – |
