Hyperglycemia (HP:0003074)
An increased concentration of glucose in the blood.
Synonyms: High blood sugar, High blood glucose
Cross References: MSH:D006943, SNOMEDCT_US:237598005, SNOMEDCT_US:80394007, UMLS:C0020456
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Maturity onset diabetes of the young | 1.106e-22 | 4.312e-21 | 4438.22 | 224380.54 |
| 2 | Type II diabetes mellitus | 2.198e-14 | 4.287e-13 | 748.13 | 23527.39 |
| 3 | Insulin secretion | 1.096e-12 | 1.425e-11 | 373.31 | 10280.78 |
| 4 | Neomycin, kanamycin and gentamicin biosynthesis | 0.002498 | 0.009741 | 555.17 | 3326.77 |
| 5 | Prolactin signaling pathway | 0.000004841 | 0.00004720 | 127.44 | 1559.65 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of peptide hormone secretion (GO:0090276) | 8.432e-16 | 2.268e-13 | 693.84 | 24082.54 |
| 2 | enteroendocrine cell differentiation (GO:0035883) | 0.000002248 | 0.00007559 | 1665.58 | 21661.60 |
| 3 | regulation of protein secretion (GO:0050708) | 3.712e-14 | 4.992e-12 | 392.95 | 12151.82 |
| 4 | nitric oxide mediated signal transduction (GO:0007263) | 7.315e-8 | 0.000002811 | 570.71 | 9377.24 |
| 5 | regulation of insulin secretion (GO:0050796) | 3.526e-12 | 3.162e-10 | 304.47 | 8029.08 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ATP-activated inward rectifier potassium channel activity (GO:0015272) | 0.000003371 | 0.0001416 | 1249.13 | 15739.23 |
| 2 | glucokinase activity (GO:0004340) | 0.002498 | 0.006556 | 555.17 | 3326.77 |
| 3 | mannokinase activity (GO:0019158) | 0.002498 | 0.006556 | 555.17 | 3326.77 |
| 4 | fructokinase activity (GO:0008865) | 0.002498 | 0.006556 | 555.17 | 3326.77 |
| 5 | fructose transmembrane transporter activity (GO:0005353) | 0.002498 | 0.006556 | 555.17 | 3326.77 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cation-transporting ATPase complex (GO:0090533) | 0.007973 | 0.05581 | 147.96 | 714.91 |
| 2 | potassium channel complex (GO:0034705) | 0.0006964 | 0.009749 | 63.82 | 463.95 |
| 3 | endosome lumen (GO:0031904) | 0.01293 | 0.06033 | 88.73 | 385.85 |
| 4 | endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116) | 0.02424 | 0.08483 | 46.16 | 171.72 |
| 5 | Golgi lumen (GO:0005796) | 0.04890 | 0.1121 | 22.32 | 67.37 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ABCC8 | REPAGLINIDE, GLICLAZIDE, GLIQUIDONE, GLIPIZIDE, NATEGLINIDE, GLIMEPIRIDE, ACETOHEXAMIDE, GLYBURIDE, STERILE TOLBUTAMIDE SODIUM, TOLAZAMIDE |
| INS | INULIN, INSULIN GLARGINE |
| KCNJ11 | GLIMEPIRIDE, GLIQUIDONE, GLIPIZIDE, GLICLAZIDE, THIAMYLAL, GLYBURIDE, STERILE TOLBUTAMIDE SODIUM, DIAZOXIDE |
| GCK | – |
| PAX4 | REPAGLINIDE |
| PDX1 | – |
| HNF4A | UREA |
| HNF1A | – |
| SLC2A2 | METFORMIN |
| NEUROD1 | REPAGLINIDE, DEFEROXAMINE |
