Hepatitis (HP:0012115)
Inflammation of the liver.
Synonyms: Liver inflammation
Cross References: MSH:D006505, SNOMEDCT_US:128241005, UMLS:C0019158
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 4.712e-12 | 5.842e-10 | 604.76 | 15772.67 |
| 2 | B cell receptor signaling pathway | 2.384e-10 | 9.853e-9 | 262.03 | 5805.76 |
| 3 | Chagas disease | 7.715e-10 | 2.392e-8 | 205.08 | 4303.17 |
| 4 | Allograft rejection | 7.523e-7 | 0.00001037 | 244.35 | 3445.31 |
| 5 | Epstein-Barr virus infection | 2.001e-10 | 9.853e-9 | 151.48 | 3383.01 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive thymic T cell selection (GO:0045059) | 0.000002248 | 0.0001192 | 1665.58 | 21661.60 |
| 2 | T cell apoptotic process (GO:0070231) | 0.000004719 | 0.0001786 | 999.25 | 12254.80 |
| 3 | B cell receptor signaling pathway (GO:0050853) | 1.451e-9 | 1.922e-7 | 443.56 | 9026.96 |
| 4 | positive regulation of B cell differentiation (GO:0045579) | 0.000008085 | 0.0002678 | 713.68 | 8368.26 |
| 5 | antigen receptor-mediated signaling pathway (GO:0050851) | 6.059e-13 | 1.606e-10 | 259.71 | 7306.12 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phospholipase binding (GO:0043274) | 0.00002041 | 0.0005919 | 416.21 | 4494.85 |
| 2 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.003495 | 0.01709 | 370.07 | 2093.27 |
| 3 | tumor necrosis factor-activated receptor activity (GO:0005031) | 0.004492 | 0.01709 | 277.53 | 1500.17 |
| 4 | non-membrane spanning protein tyrosine kinase activity (GO:0004715) | 0.0001327 | 0.001924 | 151.19 | 1349.73 |
| 5 | 1-phosphatidylinositol-3-kinase activity (GO:0016303) | 0.004990 | 0.01709 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | T cell receptor complex (GO:0042101) | 1.975e-8 | 3.753e-7 | 951.48 | 16879.14 |
| 2 | alpha-beta T cell receptor complex (GO:0042105) | 0.000003371 | 0.00003203 | 1249.13 | 15739.23 |
| 3 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.009491 | 555.17 | 3326.77 |
| 4 | CD95 death-inducing signaling complex (GO:0031265) | 0.002498 | 0.009491 | 555.17 | 3326.77 |
| 5 | death-inducing signaling complex (GO:0031264) | 0.003994 | 0.01111 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SYK | FOSTAMATINIB |
| PIK3CA | – |
| CD40LG | – |
| CD79B | POLATUZUMAB VEDOTIN |
| CD79A | – |
| CD3D | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| CD3E | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| BTK | IBRUTINIB |
| FASLG | – |
| FAS | TENIPOSIDE |
