Hand muscle weakness (HP:0030237)
Reduced strength of the musculature of the hand.
Synonyms:Hand muscle weakness
Cross References:SNOMEDCT_US:298283006, UMLS:C0239831
KEGG pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Neuroactive ligand-receptor interaction | 0.00001608 | 0.00008039 | 38.88 | 429.14 |
| 2 | Mitophagy | 0.03349 | 0.08373 | 33.04 | 112.22 |
| 3 | NOD-like receptor signaling pathway | 0.08692 | 0.1449 | 12.23 | 29.87 |
| 4 | Parkinson disease | 0.1178 | 0.1472 | 8.84 | 18.92 |
| 5 | Pathways of neurodegeneration | 0.2137 | 0.2137 | 4.57 | 7.06 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic transmission, cholinergic (GO:0007271) | 1.217e-10 | 9.611e-9 | 887.78 | 20267.77 |
| 2 | neuromuscular junction development (GO:0007528) | 1.812e-7 | 0.000003793 | 407.53 | 6326.45 |
| 3 | positive regulation of vascular associated smooth muscle cell apoptotic process (GO:1905461) | 0.002498 | 0.01644 | 555.17 | 3326.77 |
| 4 | neuromuscular process (GO:0050905) | 0.00003830 | 0.0003735 | 293.72 | 2987.15 |
| 5 | postsynaptic membrane organization (GO:0001941) | 0.00003830 | 0.0003735 | 293.72 | 2987.15 |
GO: Molecular function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099529) | 1.878e-10 | 4.882e-9 | 783.25 | 17541.62 |
| 2 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) | 8.580e-10 | 1.115e-8 | 511.90 | 10686.61 |
| 3 | transmitter-gated ion channel activity (GO:0022824) | 1.451e-9 | 1.257e-8 | 443.56 | 9026.96 |
| 4 | postsynaptic neurotransmitter receptor activity (GO:0098960) | 1.191e-7 | 7.172e-7 | 475.52 | 7581.26 |
| 5 | acetylcholine receptor activity (GO:0015464) | 1.379e-7 | 7.172e-7 | 450.47 | 7115.97 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuromuscular junction (GO:0031594) | 4.712e-12 | 7.067e-11 | 604.76 | 15772.67 |
| 2 | acetylcholine-gated channel complex (GO:0005892) | 3.267e-8 | 2.450e-7 | 778.40 | 13417.28 |
| 3 | ion channel complex (GO:0034702) | 5.841e-7 | 0.000002921 | 267.29 | 3836.51 |
| 4 | intrinsic component of mitochondrial membrane (GO:0098573) | 0.005985 | 0.01496 | 201.81 | 1032.95 |
| 5 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.01815 | 138.71 | 661.82 |
Hub genes as predicted biomarker & predicted FDA approved drugs
| Hub genes (ranked) | FDA approved drugs |
| RAPSN | – |
| CHRNA1 | – |
| CHRNE | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHRNB1 | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHRND | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| DOK7 | – |
| MUSK | – |
| SCN4A | LEVOBUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE |
| COLQ | – |
| MFN2 | – |
