Gastroesophageal reflux (HP:0002020)
A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.
Synonyms: Acid reflux, Acid reflux disease, Gastro-oesophageal reflux, GERD, Heartburn, Gastro-esophageal reflux, Gastroesophageal reflux disease
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 6.174e-12 | 7.100e-10 | 570.14 | 14715.76 |
| 2 | Long-term potentiation | 9.011e-11 | 5.182e-9 | 321.42 | 7434.41 |
| 3 | Amphetamine addiction | 2.681e-8 | 9.684e-7 | 204.36 | 3562.87 |
| 4 | ErbB signaling pathway | 6.256e-8 | 0.000001199 | 163.86 | 2717.97 |
| 5 | Circadian entrainment | 1.067e-7 | 0.000001754 | 142.63 | 2289.62 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular response to histamine (GO:0071420) | 0.000004719 | 0.0001184 | 999.25 | 12254.80 |
| 2 | excitatory chemical synaptic transmission (GO:0098976) | 0.000004719 | 0.0001184 | 999.25 | 12254.80 |
| 3 | regulation of NMDA receptor activity (GO:2000310) | 1.125e-9 | 1.412e-7 | 475.29 | 9793.38 |
| 4 | positive regulation of synapse maturation (GO:0090129) | 0.000008085 | 0.0001691 | 713.68 | 8368.26 |
| 5 | response to histamine (GO:0034776) | 0.00001010 | 0.0001937 | 624.44 | 7182.69 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glutamate-gated calcium ion channel activity (GO:0022849) | 0.000002248 | 0.0001304 | 1665.58 | 21661.60 |
| 2 | NMDA glutamate receptor activity (GO:0004972) | 0.000006290 | 0.0001401 | 832.67 | 9972.50 |
| 3 | glycine binding (GO:0016594) | 0.00001235 | 0.0001502 | 555.03 | 6273.06 |
| 4 | GABA-gated chloride ion channel activity (GO:0022851) | 0.00001750 | 0.0001692 | 454.07 | 4973.59 |
| 5 | ionotropic glutamate receptor activity (GO:0004970) | 0.00003048 | 0.0002221 | 332.92 | 3461.84 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NMDA selective glutamate receptor complex (GO:0017146) | 0.000006290 | 0.0001069 | 832.67 | 9972.50 |
| 2 | GABA-A receptor complex (GO:1902711) | 0.00003830 | 0.0003256 | 293.72 | 2987.15 |
| 3 | synaptic membrane (GO:0097060) | 0.00007266 | 0.0004941 | 207.98 | 1981.99 |
| 4 | ionotropic glutamate receptor complex (GO:0008328) | 0.0001107 | 0.0006274 | 166.33 | 1515.06 |
| 5 | neuron projection (GO:0043005) | 8.582e-8 | 0.000002918 | 53.02 | 862.66 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GRIN1 | MEMANTINE, ORPHENADRINE |
| GRIN2B | MEMANTINE, FELBAMATE, ACAMPROSATE |
| CAMK2A | – |
| GABRG2 | – |
| GABRB2 | – |
| NRXN1 | DULOXETINE |
| CACNA1B | ZICONOTIDE, ZICONOTIDE ACETATE, AMLODIPINE, LEVETIRACETAM |
| CAMK2B | – |
| ERBB4 | DACOMITINIB |
| HRAS | – |
