Exercise intolerance (HP:0003546)
A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.
Synonyms: Decreased ability to exercise, Inability to exercise, Low exercise endurance, Poor exercise tolerance
Pubmed References: PMID:10617757
Cross References: SNOMEDCT_US:267044007, UMLS:C0424551
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Glucagon signaling pathway | 1.217e-14 | 2.677e-13 | 464.10 | 14869.80 |
| 2 | Insulin signaling pathway | 3.435e-9 | 3.779e-8 | 150.44 | 2931.94 |
| 3 | Glycolysis / Gluconeogenesis | 0.000004240 | 0.00002332 | 133.43 | 1650.70 |
| 4 | Calcium signaling pathway | 0.000004013 | 0.00002332 | 55.80 | 693.40 |
| 5 | Central carbon metabolism in cancer | 0.0005336 | 0.002348 | 73.24 | 551.94 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glycogen catabolic process (GO:0005980) | 2.832e-14 | 8.923e-13 | 1998.00 | 62328.01 |
| 2 | glucan catabolic process (GO:0009251) | 2.832e-14 | 8.923e-13 | 1998.00 | 62328.01 |
| 3 | cellular polysaccharide catabolic process (GO:0044247) | 4.118e-14 | 8.923e-13 | 1816.27 | 55978.80 |
| 4 | cellular glucan metabolic process (GO:0006073) | 1.038e-11 | 1.349e-10 | 1903.14 | 48133.11 |
| 5 | glycogen metabolic process (GO:0005977) | 9.244e-13 | 1.502e-11 | 868.13 | 24055.55 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | calmodulin-dependent protein kinase activity (GO:0004683) | 1.812e-7 | 0.000003080 | 407.53 | 6326.45 |
| 2 | 1,4-alpha-oligoglucan phosphorylase activity (GO:0004645) | 0.002498 | 0.01485 | 555.17 | 3326.77 |
| 3 | fructose binding (GO:0070061) | 0.002997 | 0.01485 | 444.11 | 2580.41 |
| 4 | phosphofructokinase activity (GO:0008443) | 0.003495 | 0.01485 | 370.07 | 2093.27 |
| 5 | intramolecular transferase activity, phosphotransferases (GO:0016868) | 0.004492 | 0.01527 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | muscle myosin complex (GO:0005859) | 0.007476 | 0.06711 | 158.54 | 776.21 |
| 2 | myofibril (GO:0030016) | 0.01342 | 0.06711 | 85.32 | 367.79 |
| 3 | filopodium (GO:0030175) | 0.02863 | 0.08148 | 38.86 | 138.07 |
| 4 | actin filament (GO:0005884) | 0.03543 | 0.08148 | 31.17 | 104.12 |
| 5 | actin-based cell projection (GO:0098858) | 0.04074 | 0.08148 | 26.98 | 86.34 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PYGM | – |
| PFKM | – |
| PGAM2 | – |
| PHKA1 | – |
| MYH6 | – |
| ENO3 | – |
| PHKA2 | – |
| ACTA1 | – |
| PHKB | – |
| PHKG2 | – |
