Emotional lability (HP:0000712)
Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances.
Synonyms: Emotional instability, Mood changes, Mood swings, Mood alterations, Mood lability
Pubmed References: PMID:23902698
Cross References: SNOMEDCT_US:18963009, UMLS:C0085633
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thermogenesis | 3.007e-12 | 5.412e-11 | 204.97 | 5437.89 |
| 2 | Oxidative phosphorylation | 2.958e-9 | 2.662e-8 | 155.17 | 3047.38 |
| 3 | Diabetic cardiomyopathy | 2.479e-8 | 1.488e-7 | 99.96 | 1750.56 |
| 4 | Retrograde endocannabinoid signaling | 5.840e-7 | 0.000002530 | 91.88 | 1318.78 |
| 5 | Non-alcoholic fatty liver disease | 7.027e-7 | 0.000002530 | 87.59 | 1240.99 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NADH dehydrogenase complex assembly (GO:0010257) | 9.480e-14 | 1.659e-12 | 575.13 | 17246.54 |
| 2 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 9.480e-14 | 1.659e-12 | 575.13 | 17246.54 |
| 3 | mitochondrial respiratory chain complex assembly (GO:0033108) | 1.450e-12 | 1.692e-11 | 355.46 | 9689.66 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.570e-9 | 1.499e-8 | 380.10 | 7518.11 |
| 5 | aerobic electron transport chain (GO:0019646) | 1.129e-10 | 8.497e-10 | 306.54 | 7021.22 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NADH dehydrogenase activity (GO:0003954) | 0.000004719 | 0.00001298 | 999.25 | 12254.80 |
| 2 | oxidoreduction-driven active transmembrane transporter activity (GO:0015453) | 4.283e-11 | 4.712e-10 | 376.17 | 8980.56 |
| 3 | NADH dehydrogenase (quinone) activity (GO:0050136) | 1.637e-9 | 6.003e-9 | 429.23 | 8683.34 |
| 4 | NADH dehydrogenase (ubiquinone) activity (GO:0008137) | 1.637e-9 | 6.003e-9 | 429.23 | 8683.34 |
| 5 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) | 0.003495 | 0.007322 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial respiratory chain complex I (GO:0005747) | 3.494e-9 | 2.621e-8 | 350.04 | 6815.94 |
| 2 | respiratory chain complex I (GO:0045271) | 3.494e-9 | 2.621e-8 | 350.04 | 6815.94 |
| 3 | mitochondrial envelope (GO:0005740) | 3.161e-7 | 8.832e-7 | 107.68 | 1611.67 |
| 4 | mitochondrial membrane (GO:0031966) | 3.123e-8 | 1.562e-7 | 63.26 | 1093.29 |
| 5 | mitochondrial inner membrane (GO:0005743) | 2.711e-7 | 8.832e-7 | 60.89 | 920.69 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NDUFS3 | – |
| NDUFS1 | – |
| NDUFA2 | – |
| NDUFA9 | – |
| NDUFAF2 | – |
| NDUFAF6 | – |
| COX15 | – |
| TACO1 | – |
| PDHA1 | – |
| C9orf72 | – |
