Elevated erythrocyte sedimentation rate (HP:0003565)
An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
Synonyms: High ESR, Elevated ESR, Elevated sedimentation rate, High erythrocyte sedimentation rate, Increased erythrocyte sedimentation rate, Raised erythrocyte sedimentation rate
Pubmed References: PMID:10524488
Cross References: SNOMEDCT_US:165468009, UMLS:C0151632
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Autoimmune thyroid disease | 0.0003059 | 0.004690 | 97.74 | 790.95 |
| 2 | Influenza A | 0.00007175 | 0.001920 | 50.26 | 479.64 |
| 3 | Antigen processing and presentation | 0.0006621 | 0.006942 | 65.51 | 479.51 |
| 4 | NOD-like receptor signaling pathway | 0.00008348 | 0.001920 | 47.70 | 447.96 |
| 5 | Th1 and Th2 cell differentiation | 0.0009195 | 0.006942 | 55.28 | 386.48 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of MHC class I biosynthetic process (GO:0045345) | 0.000002248 | 0.0001704 | 1665.58 | 21661.60 |
| 2 | regulation of MHC class I biosynthetic process (GO:0045343) | 0.000004719 | 0.0002186 | 999.25 | 12254.80 |
| 3 | negative regulation of interleukin-1 production (GO:0032692) | 3.628e-7 | 0.0001009 | 316.87 | 4699.01 |
| 4 | regulation of interleukin-1 production (GO:0032652) | 0.00002690 | 0.0006798 | 356.71 | 3753.85 |
| 5 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.01472 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.02371 | 444.11 | 2580.41 |
| 2 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.02371 | 317.19 | 1751.86 |
| 3 | MHC class II receptor activity (GO:0032395) | 0.004990 | 0.02371 | 246.68 | 1307.49 |
| 4 | phosphatidate phosphatase activity (GO:0008195) | 0.006482 | 0.02371 | 184.98 | 932.06 |
| 5 | peptidoglycan binding (GO:0042834) | 0.007476 | 0.02371 | 158.54 | 776.21 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.07347 | 184.98 | 932.06 |
| 2 | MHC protein complex (GO:0042611) | 0.009957 | 0.07701 | 116.79 | 538.34 |
| 3 | clathrin-coated endocytic vesicle (GO:0045334) | 0.0007857 | 0.02671 | 59.96 | 428.66 |
| 4 | lumenal side of endoplasmic reticulum membrane (GO:0098553) | 0.01392 | 0.07701 | 82.15 | 351.18 |
| 5 | integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) | 0.01392 | 0.07701 | 82.15 | 351.18 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PTPN22 | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| CIITA | – |
| MEFV | – |
| IL2RA | BASILIXIMAB, DACLIZUMAB, ALDESLEUKIN, DENILEUKIN DIFTITOX, CETIRIZINE |
| LPIN2 | – |
| NLRP3 | ANAKINRA, TRICLOCARBAN |
| TMEM173 | – |
| NLRP12 | – |
