Elevated circulating thyroid-stimulating hormone concentration (HP:0002925)
Increased concentration of thyroid-stimulating hormone (TSH) in the blood circulation.
Synonyms: High TSH, TSH excess, Elevated thyroid stimulating hormone, Elevated thyroid stimulating hormone levels, Increased serum thyroid-stimulating hormone, Increased thyroid-stimulating hormone, Increased thyroid-stimulating hormone level, Increased thyrotropin level, Thyroid-stimulating hormone excess
Cross References: SNOMEDCT_US:309080005, UMLS:C0586553
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone synthesis | 3.764e-8 | 3.012e-7 | 187.03 | 3197.34 |
| 2 | Autoimmune thyroid disease | 0.000002081 | 0.000008324 | 170.91 | 2236.02 |
| 3 | Tyrosine metabolism | 0.01786 | 0.04762 | 63.35 | 255.00 |
| 4 | Regulation of lipolysis in adipocytes | 0.02717 | 0.05434 | 41.02 | 147.91 |
| 5 | Thyroid hormone signaling pathway | 0.05889 | 0.08859 | 18.40 | 52.10 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | thyroid hormone generation (GO:0006590) | 1.975e-8 | 0.000002272 | 951.48 | 16879.14 |
| 2 | thyroid gland development (GO:0030878) | 0.000006290 | 0.0003617 | 832.67 | 9972.50 |
| 3 | lung morphogenesis (GO:0060425) | 0.002498 | 0.01914 | 555.17 | 3326.77 |
| 4 | epithelial tube branching involved in lung morphogenesis (GO:0060441) | 0.002997 | 0.01914 | 444.11 | 2580.41 |
| 5 | equilibrioception (GO:0050957) | 0.002997 | 0.01914 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.02058 | 555.17 | 3326.77 |
| 2 | anion:sodium symporter activity (GO:0015373) | 0.002498 | 0.02058 | 555.17 | 3326.77 |
| 3 | thyroid hormone transmembrane transporter activity (GO:0015349) | 0.002997 | 0.02058 | 444.11 | 2580.41 |
| 4 | cAMP-dependent protein kinase inhibitor activity (GO:0004862) | 0.003994 | 0.02058 | 317.19 | 1751.86 |
| 5 | pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165) | 0.003994 | 0.02058 | 317.19 | 1751.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | catenin complex (GO:0016342) | 0.01540 | 0.07813 | 73.93 | 308.54 |
| 2 | integral component of Golgi membrane (GO:0030173) | 0.02717 | 0.07813 | 41.02 | 147.91 |
| 3 | extracellular membrane-bounded organelle (GO:0065010) | 0.02766 | 0.07813 | 40.27 | 144.50 |
| 4 | extracellular vesicle (GO:1903561) | 0.02912 | 0.07813 | 38.18 | 135.03 |
| 5 | intrinsic component of Golgi membrane (GO:0031228) | 0.02960 | 0.07813 | 37.53 | 132.12 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SLC5A5 | – |
| TSHR | THYROTROPIN ALFA |
| TG | ACEBUTOLOL, AMINOGLETETHIMIDE |
| NKX2-1 | – |
| TPO | CARBIMAZOLE, METHIMAZOLE, PROPYLTHIOURACIL |
| SLC16A2 | – |
| SECISBP2 | – |
| SLC35A2 | – |
| PRKAR1A | – |
| CDH23 | METHYLPHENIDATE |
