LONG COVID – Elevated circulating creatinine concentration – LCGAR: Long COVID Gene Association Resource

Elevated circulating creatinine concentration (HP:0003259)

An increased amount of creatinine in the blood.

Synonyms: Elevated creatinine, High blood creatinine level, Increased creatinine, Increased serum creatinine, Elevated serum creatinine

Cross References: SNOMEDCT_US:166717003, UMLS:C0700225

KEGG Pathway

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	Maturity onset diabetes of the young	0.01293	0.05177	88.73	385.85
2	Fanconi anemia pathway	0.02668	0.05177	41.80	151.46
3	Cytosolic DNA-sensing pathway	0.03106	0.05177	35.71	123.99
4	Complement and coagulation cascades	0.04171	0.05213	26.33	83.66
5	Wnt signaling pathway	0.07998	0.07998	13.35	33.72

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	protein localization to cilium (GO:0061512)	5.841e-7	0.00003739	267.29	3836.51
2	DNA catabolic process, exonucleolytic (GO:0000738)	0.002498	0.01743	555.17	3326.77
3	nephron tubule development (GO:0072080)	0.002997	0.01743	444.11	2580.41
4	pronephros development (GO:0048793)	0.002997	0.01743	444.11	2580.41
5	protein localization to ciliary membrane (GO:1903441)	0.003495	0.01864	370.07	2093.27

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	MutLalpha complex binding (GO:0032405)	0.003495	0.01454	370.07	2093.27
2	MutSalpha complex binding (GO:0032407)	0.003495	0.01454	370.07	2093.27
3	5′-flap endonuclease activity (GO:0017108)	0.003994	0.01454	317.19	1751.86
4	flap endonuclease activity (GO:0048256)	0.004492	0.01454	277.53	1500.17
5	ubiquitination-like modification-dependent protein binding (GO:0140035)	0.004990	0.01454	246.68	1307.49

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	non-motile cilium (GO:0097730)	0.01589	0.06355	71.54	296.32
2	motile cilium (GO:0031514)	0.03349	0.08931	33.04	112.22
3	cilium (GO:0005929)	0.005910	0.04728	21.02	107.83
4	endoplasmic reticulum lumen (GO:0005788)	0.1337	0.2675	7.71	15.51
5	endoplasmic reticulum membrane (GO:0005789)	0.3041	0.4689	3.01	3.59

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