Elevated circulating alkaline phosphatase concentration (HP:0003155)
Abnormally increased serum levels of alkaline phosphatase activity.
Synonyms: Elevated ALP, Elevated alkaline phosphatase, Greatly elevated alkaline phosphatase, High serum alkaline phosphatase, Increased alkaline phosphatase, Increased serum alkaline phosphatase, Hyperphosphatasemia, Hyperphosphatasia
Pubmed References: PMID:29083622
Cross References: UMLS:C0750857
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 3.101e-19 | 3.721e-18 | 2452.58 | 104522.58 |
| 2 | Melanoma | 0.03543 | 0.1517 | 31.17 | 104.12 |
| 3 | Parathyroid hormone synthesis, secretion and action | 0.05176 | 0.1517 | 21.04 | 62.31 |
| 4 | Breast cancer | 0.07113 | 0.1517 | 15.10 | 39.92 |
| 5 | Gastric cancer | 0.07207 | 0.1517 | 14.90 | 39.18 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | preassembly of GPI anchor in ER membrane (GO:0016254) | 9.177e-21 | 1.377e-19 | 4662.00 | 215093.20 |
| 2 | GPI anchor metabolic process (GO:0006505) | 2.199e-22 | 1.320e-20 | 3994.00 | 199175.49 |
| 3 | GPI anchor biosynthetic process (GO:0006506) | 7.441e-22 | 2.232e-20 | 3327.67 | 161890.56 |
| 4 | glycolipid biosynthetic process (GO:0009247) | 5.437e-21 | 1.087e-19 | 2494.75 | 116407.64 |
| 5 | protein lipidation (GO:0006497) | 2.078e-19 | 2.494e-18 | 1504.68 | 64727.57 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.009366 | 555.17 | 3326.77 |
| 2 | acetylglucosaminyltransferase activity (GO:0008375) | 0.000001538 | 0.00002308 | 189.95 | 2542.46 |
| 3 | mannosyltransferase activity (GO:0000030) | 0.00005170 | 0.0003877 | 249.63 | 2463.82 |
| 4 | fibroblast growth factor receptor binding (GO:0005104) | 0.01144 | 0.03433 | 100.85 | 450.83 |
| 5 | O-acyltransferase activity (GO:0008374) | 0.01490 | 0.03726 | 76.48 | 321.69 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endoplasmic reticulum membrane (GO:0005789) | 1.048e-10 | 7.339e-10 | 109.58 | 2517.98 |
| 2 | Golgi lumen (GO:0005796) | 0.04890 | 0.1712 | 22.32 | 67.37 |
| 3 | endoplasmic reticulum lumen (GO:0005788) | 0.1337 | 0.3120 | 7.71 | 15.51 |
| 4 | Golgi membrane (GO:0000139) | 0.2125 | 0.3719 | 4.60 | 7.13 |
| 5 | bounding membrane of organelle (GO:0098588) | 0.3237 | 0.4103 | 2.79 | 3.15 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PIGV | – |
| PIGA | – |
| PIGL | – |
| PIGB | – |
| PIGQ | – |
| PIGY | – |
| PGAP2 | – |
| PIGW | – |
| FGF23 | BUROSUMAB |
| PHEX | CALCITRIOL |
