Edema (HP:0000969)
An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
Synonyms: Fluid retention, Water retention, Hydrops, Oedema, Dropsy
Comment: Edema may be related to one or more of the following factors: 1) increased capillary hydrostatic pressure, 2) decreased osmotic pressure of plasma, 3) decreased tissue tension and lymphatic drainage, 4) increased osmotic pressure of tissue fluids, and 5) increased capillary permeability.
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Phototransduction | 0.00008446 | 0.002864 | 191.96 | 1800.45 |
| 2 | Thyroid cancer | 0.0001485 | 0.002864 | 142.54 | 1256.48 |
| 3 | Bladder cancer | 0.0001826 | 0.002864 | 127.89 | 1100.92 |
| 4 | Endometrial cancer | 0.0003664 | 0.002864 | 88.99 | 704.07 |
| 5 | VEGF signaling pathway | 0.0003792 | 0.002864 | 87.43 | 688.70 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | rhodopsin mediated signaling pathway (GO:0016056) | 0.00001235 | 0.0008240 | 555.03 | 6273.06 |
| 2 | phototransduction, visible light (GO:0007603) | 0.00002354 | 0.0008240 | 384.17 | 4094.01 |
| 3 | retinal rod cell development (GO:0046548) | 0.003495 | 0.01439 | 370.07 | 2093.27 |
| 4 | vitamin A metabolic process (GO:0006776) | 0.003495 | 0.01439 | 370.07 | 2093.27 |
| 5 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 0.00006709 | 0.001565 | 217.03 | 2085.58 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | U2 snRNA binding (GO:0030620) | 0.002498 | 0.01597 | 555.17 | 3326.77 |
| 2 | 11-cis retinal binding (GO:0005502) | 0.002997 | 0.01597 | 444.11 | 2580.41 |
| 3 | pre-mRNA intronic binding (GO:0097157) | 0.003994 | 0.01597 | 317.19 | 1751.86 |
| 4 | U1 snRNA binding (GO:0030619) | 0.003994 | 0.01597 | 317.19 | 1751.86 |
| 5 | retinal binding (GO:0016918) | 0.004492 | 0.01597 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | U2-type catalytic step 1 spliceosome (GO:0071006) | 0.005985 | 0.05120 | 201.81 | 1032.95 |
| 2 | U5 snRNP (GO:0005682) | 0.008469 | 0.05120 | 138.71 | 661.82 |
| 3 | Golgi-associated vesicle membrane (GO:0030660) | 0.01194 | 0.05120 | 96.46 | 427.12 |
| 4 | U2-type catalytic step 2 spliceosome (GO:0071007) | 0.01490 | 0.05120 | 76.48 | 321.69 |
| 5 | ciliary membrane (GO:0060170) | 0.01540 | 0.05120 | 73.93 | 308.54 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NR2E3 | – |
| RHO | – |
| NRL | – |
| RLBP1 | – |
| PRPF8 | – |
| PRPH2 | – |
| PDE6G | PENTOXIFYLLINE |
| RP9 | – |
| KRAS | PANITUMUMAB, CETUXIMAB |
| NRAS | BINIMETINIB |
